The Illinois Precision Medicine Consortium (IPMC) All of Us Research Program Site

伊利诺伊州精准医学联盟 (IPMC) All of Us 研究计划网站

• 批准号: 10872859
• 负责人: Habibul Ahsan
• 金额: $ 1206万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10872859
• 关键词: Acceleration; Accounting; Adult; Age; All of Us Research Program; Amber; Area; Arthritis; Automobile Driving; Award; Awareness; Biomedical Research; COVID-19 pandemic; Catchment Area; Cessation of life; Chicago; Childhood; Church; Clinical; Clinical Informatics; Collaborations; Collection; Communities; Community Health; Complex; Computers; Coronary heart disease; Data; Dedications; Dementia; Disease; Education; Electronic Health Record; Electronic Mail; Enrollment; Ensure; Environmental Exposure; Equity; Ethnic Origin; Ethnic Population; Evaluation; Event; Family; Friends; Funding; Genetic; Genomics; Geography; Goals; Graduate Education; Greenland; Hand; Health; Health Personnel; Health Sciences; Health Service Area; Health Technology; Health care facility; Health system; Healthcare; Healthcare Systems; Hour; Human; Illinois; Income; Indiana; Infrastructure; Institution; Internet; Investments; Knowledge; Leadership; Link; Longevity; Malignant Neoplasms; Methods; Minority Groups; Minority-Serving Institution; Modality; Municipalities; Observational epidemiology; Operations Research; Participant; Patients; Pediatrics; Performance; Persons; Physicians; Play; Population; Population Heterogeneity; Positioning Attribute; Precision Health; Prevention; Protocols documentation; Provider; Race; Research; Research Activity; Research Personnel; Residential Facilities; Resources; Role; Rural; Rural Population; Saliva; Schools; Science; Scientist; Services; Site; Source; Stroke; Structure; Students; System; Target Populations; Telephone; Text Messaging; Training; Training Programs; United States; United States National Institutes of Health; Universities; Voice; Work; career; clinical phenotype; clinical research site; cohort; community organizations; community partnership; cultural competence; data exchange; data quality; demographics; digital; digital technology; disability; disparity reduction; empowerment; epidemiology study; equity, diversity, and inclusion; expectation; experience; flexibility; follow-up; health disparity; health equity; human disease; implementation strategy; improved; innovation; insight; interest; interoperability; mHealth; member; metropolitan; outreach; patient population; podcast; population based; population health; precision medicine; programs; racial population; recruit; resilience research; response; skills; suburb; success; synergism; trend; undergraduate education; web site

1.1. ABSTRACT The first 7 years of the All of Us Research Program (AoURP) Illinois Precision Medicine Consortium (IPMC) award has created an impetus for precision health collaboration in Illinois that will leave a positive legacy for decades both locally and nationally. During the first 5 years of enrollment, the IPMC has drawn strength from our institutional differences, varied scientific interests and expertise, broad geographic catchment areas, and diverse patient populations. To date, we have enrolled a cohort of nearly 43,000 participants from Chicago and greater Illinois, accounting for nearly 10% of the core AoURP participants nationwide – exceeding all expectations for diversity through high enrollment (87%) of those underrepresented in biomedical research (UBR), despite a decreasing trend nationally. Through the COVID-19 pandemic, the IPMC has proven that we can evolve and thrive in a new research context, pivoting operationally while ensuring representation. This is important as the AoURP seeks new target populations (i.e., pediatric) and implementation approaches. The experience of leading the AoURP in Illinois has generated insights, knowledge, best practices, new ideas, and partners to continue and build upon our work in Chicago and throughout Illinois. This includes a recognition of the crucial role that authentic and longstanding engagement plays in developing inclusive biomedical research. We now have fully developed (and constantly expanding) clinical and community infrastructure, stakeholder buy-in, and integrated workflows. These will continue to guide IPMC performance and implementation strategies, supported by intentional engagement investment and integrated expertise. We have identified new scientific partnerships at our Health Provider Organizations (HPOs) and MPIs, now including an additional minority serving institution (MSI) with significant UBR engagement expertise. The IPMC offers this proposal, to fulfill or exceed the AoURP requirements for OTA-22-006 Areas of Interest (AOIs). Under the direction of the AoURP and NIH, for AOI 1- Community, Participant and Provider Engagement, Enrollment and Retention, we will work with AoURP leadership and stakeholders nationally and IPMC-wide to engage and recruit a targeted 50,000 diverse core participants in Illinois during the 5-year award period. We plan to recruit at least 85% UBR into the AoURP by leveraging established leadership and frontline teams, infrastructure, workflows, and new engagement partnerships. We will work collectively to achieve the engagement, enrollment, and retention (active and passive) milestones outlined by the AoURP and implement the protocol fully and flexibly as national approaches, milestone priorities, and strategies and priorities evolve. To achieve these aims, the IPMC proposes to maintain our HPO institutional membership (University of Chicago, Northwestern University, University of Illinois Chicago, NorthShore University HealthSystem, and Rush University, with subcontracts at University of Illinois Urbana-Champaign and University of Illinois Peoria) with Dr. Habibul Ahsan serving as the contact PI with MPIs Daviglus, Greenland, Aschebrook, Ho, Shah, Sanders, Pirzada, and Soares. We will also add a crucial engagement partnership with Governors State University, an MSI with Drs. Balthazar and Roberson joining as MPIs. Over the last 5 years, IPMC partners have demonstrated complementary reach into diverse patient populations while balancing key AoURP metrics (UBR engagement, high quality data, enrollment, and retention). We are confident that our 5-year plan will bring significant value to the AoURP, with an engaged and diverse participant population based in Illinois that will ultimately enable discovery and promote equity in the communities we collectively serve and beyond.

1.1. 摘要 伊利诺伊州精准医学全民研究计划 (AoURP) 的前 7 年 联盟（IPMC）奖项为伊利诺伊州精准医疗合作创造了动力 在最初的五年里，这将为当地和全国留下积极的遗产。 在招生方面，IPMC 从我们不同、科学的机构差异中汲取了力量 兴趣和专业知识、广阔的地理覆盖区域以及多样化的患者群体。 迄今为止，我们已经招募了来自芝加哥和大伊利诺伊州的近 43,000 名参与者， 占全国 AoURP 核心参与者的近 10%——超过所有参与者 通过高入学率（87%）实现多样性的期望 生物医学研究（UBR），尽管在全国范围内呈下降趋势，因为 COVID-19。 大流行期间，IPMC 已经证明我们可以在新的研究背景下发展和繁荣， 在确保代表性的同时进行业务调整很重要，因为 AoURP 正在寻求新的方向。 目标人群（即儿科）和实施方法。 伊利诺伊州的 AoURP 产生了见解、知识、最佳实践、新想法和合作伙伴 继续并以我们在芝加哥和整个伊利诺伊州的工作为基础，这包括认可。 真正和长期的参与在发展包容性方面发挥着至关重要的作用 我们现在已经充分发展（并不断扩大）临床和生物医学研究。 社区基础设施、利益相关者的支持和集成的工作流程将继续发展。 在有意参与的支持下，指导 IPMC 绩效和战略实施 我们在健康领域确定了新的科学合作伙伴关系。 提供商组织 (HPO) 和 MPI，现在包括额外的少数服务 具有丰富的 UBR 参与专业知识的机构 (MSI) IPMC 提供此提案，以 满足或超过 OTA-22-006 感兴趣区域 (AOI) 的 AoURP 要求。 AoURP 和 NIH 的方向，针对 AOI 1 - 社区、参与者和提供者参与， 注册和保留，我们将与 AoURP 领导层和全国利益相关者合作， IPMC 范围内将在伊利诺伊州吸引和招募目标 50,000 名不同的核心参与者 我们计划利用 5 年奖励期招募至少 85% 的 UBR 加入 AoURP。 建立领导层和一线团队、基础设施、工作流程和新的参与 我们将共同努力实现参与、入学和保留。 AoURP 概述的（主动和被动）里程碑并全面实施该协议 随着国家方法、里程碑优先事项以及战略和优先事项的发展而灵活地进行。 为了实现这些目标，IPMC 建议维持我们的 HPO 机构成员资格 （芝加哥大学、西北大学、伊利诺伊大学芝加哥北岸分校 University HealthSystem 和拉什大学，在伊利诺伊大学有分包合同 厄巴纳-香槟分校和伊利诺伊大学皮奥里亚分校），Habibul Ahsan 博士担任 与 MPI Daviglus、Greenland、Aschebrook、Ho、Shah、Sanders、Pirzada 和 Soares 联系 PI。 我们还将增加与州长州立大学的重要合作，该大学是一个 MSI Balthazar 和 Roberson 博士作为 MPI 加入。 在过去的 5 年里，IPMC 合作伙伴已经加入。 在平衡关键 AoURP 的同时，展示了对不同患者群体的互补影响 指标（UBR 参与度、高质量数据、注册率和保留率）我们对此充满信心。 我们的 5 年计划将为 AoURP 带来巨大的价值，其中包括积极参与和多元化的 位于伊利诺伊州的人口最终将实现发现并促进公平 在我们共同服务的社区内外。