Pacific Center for Genome Research

太平洋基因组研究中心

• 批准号: 10749842
• 负责人: Youping Deng
• 金额: $ 260.55万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749842
• 关键词: Address; African American population; Area; Asian Americans; Award; Biogenesis; Biomedical Research; Cancer health equity; Centers of Research Excellence; Communicable Diseases; Communities; Companions; Core Facility; Creativeness; Data; Data Science; Development; Diabetes Mellitus; Disease; Disparity; Doctor' s Degree; Ensure; Epidemiologist; Ethnic Population; Etiology; Faculty; Fostering; Foundations; Fruit; Funding; Genetic; Genome; Genomics; Goals; Hawaii; Health; Health Benefit; Health Occupations; Hispanic Populations; Human; Individual; Infrastructure; Institution; Interdisciplinary Study; Investigation; Investments; Knowledge; Latino Population; Malignant Neoplasms; Malignant neoplasm of lung; Mentors; Minority-Serving Institution; Mission; Molecular; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Outcome; Pacific Islands; Population; Postdoctoral Fellow; Productivity; Prognosis; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Factors; Science; Scientist; Technology; Training Programs; Training and Education; Underrepresented Populations; Underserved Population; Universities; Workforce Development; career; career development; community based research; community engagement; design; disease disparity; disease prognosis; disorder risk; doctoral student; epigenome; experience; feeding; genome resource; genome sciences; genomic data; health disparity; health equity; health outcome disparity; human disease; improved; innovation; member; method development; microbiome; multi-ethnic; multidisciplinary; non-genetic; novel; precision nutrition; programs; research facility; senior faculty; skills training; synergism; undergraduate student; underserved community

ABSTRACT The proposed Pacific Center for Genome Research (PCGR) at the University of Hawaii at Manoa (UHM) aims to grow and support Genomic Research workforce at UHM, a Minority Serving Institution (MSI), which has a mission to serve historically underrepresented population in biomedical research, namely, Native Hawaiians and other Pacific Islanders. UHM awards doctorate degrees in the health professions and the sciences related to health. We will support a multi-investigator, interdisciplinary team to develop two interrelated and highly innovative genomic research projects, along with three cores, namely, Administrative Core, Genomic Workforce Development Core, and Community Engagement Core. Our two projects address critical issues in genomics including: methods development; genomics of disease; genomic data science and computational genomics; and genomics and health equity. Along with its scientific goals, the proposed UHM PCGR will substantially expand the pool of diverse genomic scientists and researchers at UHM who can perform innovative genomics research by providing didactic, practicum and research activities and experiences that are aligned with the research projects. Through the proposed initiative, genomic research capacity will be increased in UHM. The strength and diversity of the genomics research workforce and thinkforce will be enhanced at all career levels of undergraduate students, master and PhD students, postdoctoral fellows, and junior faculty members. We will identify the most motivated faculty and early stage investigators, particularly those from underrepresented backgrounds, for careers in genome research. We will identify senior faculty to serve on mentoring teams for new and early-stage investigators, and implement a Team-Science Mentoring Bootcamp for personalized education and skills training. We will enhance, consolidate and sustain core facilities and resources for genome research. We will implement objective criteria and metrics to evaluate core needs and usage, and core- dependent research productivity. Innovation and creativity will be amplified by bringing new researchers and novel ideas into the genomics. Participation of underrepresented populations and underserved communities that experience health disparities (including understudied Asian Americans, African Americans, Hispanics/Latinos, and importantly, Native Hawaiians and other Pacific Islanders) will be increased in genomics research. Institutional investments will ensure the sustainability of the proposed PCGR to provide the infrastructure and resources for a new era of research excellence on the science of genome research. We also appreciate the opportunity to become a member of the consortium together with other Centers funded under this FOA and the companion FPA, and develop best practices and opportunities for synergy among Centers. We are excited to share resources, data, and experience we accumulate in our UHM Center to Centers of other MSIs.

抽象的 夏威夷大学马诺阿分校 (UHM) 拟议的太平洋基因组研究中心 (PCGR) 的目标 发展和支持 UHM 的基因组研究队伍，该机构是一家少数族裔服务机构 (MSI)，该机构拥有 使命是为生物医学研究中历史上代表性不足的人群提供服务，即夏威夷原住民和 其他太平洋岛民。 UHM 授予健康专业和相关科学博士学位 健康。我们将支持多研究者、跨学科团队开发两个相互关联且高度相关的研究 创新基因组研究项目，以及三个核心，即行政核心、基因组劳动力 开发核心和社区参与核心。我们的两个项目解决基因组学的关键问题 包括：方法开发；疾病基因组学；基因组数据科学和计算基因组学；和 基因组学和健康公平。除了其科学目标之外，拟议的 UHM PCGR 将大幅扩展 UHM 的多元化基因组科学家和研究人员可以进行创新基因组学研究 通过提供与研究相一致的教学、实践和研究活动和经验 项目。通过拟议的举措，UHM 的基因组研究能力将得到提高。实力和 基因组学研究队伍和思想力量的多样性将在各个职业层面得到加强 本科生、硕士生和博士生、博士后研究员和初级教师。我们将 确定最积极的教师和早期研究人员，特别是来自代表性不足的教师和早期研究人员 背景，从事基因组研究的职业。我们将确定高级教师担任指导团队 新的和早期的研究人员，并实施团队科学指导训练营以实现个性化 教育和技能培训。我们将加强、巩固和维持基因组核心设施和资源 研究。我们将实施客观标准和指标来评估核心需求和使用情况，以及核心- 依赖的研究生产力。通过引进新的研究人员和 基因组学的新颖想法。代表性不足的人群和服务不足的社区的参与 经历健康差异（包括未充分研究的亚裔美国人、非裔美国人、西班牙裔/拉丁裔、 重要的是，夏威夷原住民和其他太平洋岛民）将增加基因组学研究。 机构投资将确保拟议的 PCGR 的可持续性，以提供基础设施和 基因组研究科学卓越研究新时代的资源。我们也很欣赏 有机会与本 FOA 资助的其他中心一起成为联盟成员， 配合 FPA，并开发最佳实践和机会以实现中心之间的协同作用。我们很高兴 将我们在 UHM 中心积累的资源、数据和经验分享给其他 MSI 的中心。