Bioinformatics Core

生物信息学核心

基本信息

批准号：
10576204
负责人：
Youping Deng
金额：
$ 19.35万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-14 至 2023-07-13
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10576204
关键词：
Adopted Adoption Award Basic Science Bioinformatics Biological Sciences Biology Biomedical Research Biotechnology Businesses Caliber Centers of Research Excellence Clinical Sciences Collaborations Communicable Diseases Communities Community of Practice Core Facility Custom Data Data Analyses Databases Development Discipline Disease Educational workshop Effectiveness Emerging Communicable Diseases Ensure Epigenetic Process Equilibrium Extramural Activities Faculty Fostering Funding Funding Agency Generations Genetic Genomics Growth Hawaii Health Hospitals Human Infectious Diseases Research Information Technology Infrastructure Institution Institutionalization Knowledge Letters Marketing Medicine Methods Mission Needs Assessment Occupations Performance Phase Play Positioning Attribute Preventive Privatization Procedures Process Rapid diagnostics Research Research Personnel Resources Risk Role Science Scientific Inquiry Services Source Strategic Planning Stream Surveys System Techniques Technology Time Training Training and Education Translational Research Universities Vaccines Work base big-data science bioinformatics infrastructure bioinformatics resource bioinformatics tool biological research cohesion complex biological systems computing resources cyber infrastructure design empowered improved next generation sequencing operation outreach personalized predictions prevent programs satisfaction success therapeutically effective tool user-friendly web portal

项目摘要

Project Summary for the Bioinformatics Core Explosive growth in powerful bioinformatics tools and continued refinements in well-annotated databases have accelerated the acquisition of new knowledge about the myriad genetic and epigenetic determinants of infectious diseases and other diseases that cause untold human suffering. In this regard, big-data science holds the promise for personalized, predictive, preventive and participatory medicine to improve human health and prevent disease. Thus, the importance of sustaining the Bioinformatics Core cannot be overstated. During COBRE Phase II, the Bioinformatics Core placed a major emphasis on providing customized support and collaborative services, on developing new and improved bioinformatics tools, and on conducting intensive educational courses and hands-on training workshops. The Phase III COBRE objective of facilitating the transition of the Bioinformatics Core into a sustainable state- of-the-art core facility capable of supporting high-caliber research on new, emerging and re-emerging infectious diseases, as well as other fields of scientific inquiry, will be achieved by (1) enhancing and streamlining core operations; (2) growing and diversifying the user base, capability, capacity and reach; and (3) strengthening the core infrastructure. For Aim 1, needs assessments and user satisfaction surveys will be conducted to ensure efficiency and effectiveness of core operations at the core/user interface and user services. For Aim 2, outreach and marketing activities will be expanded to other local academic institutions, biotech companies and hospitals beyond the UH System, and strong partnerships will be formed with similar cores located in other COBRE, INBRE and IDeA-CTR programs to further grow and diversify the core user base and to acquire new tools and techniques. And for Aim 3, institutionalization and phased-in business plans will be developed during the Phase III COBRE to draw on intramural and extramural sources for sustainability. It is envisioned that the Bioinformatics Core will achieve each of the above-stated specific aims. A strong commitment by the President of the UH System to fully support the Bioinformatics Core infrastructure, with professional positions and support staff, within the next five years is part of a larger strategic plan to institutionalize bioinformatics as one of the four principal pillars in the Division of Cyberinfrastructure. Thus, there is every reason to be optimistic that the Bioinformatics Core will be transformed into a system-wide bioinformatics resource to confront the challenges of big-data science.

生物信息学核心项目摘要强大的生物信息学工具的爆炸性增长和注释良好的数据库的持续改进已经加速了对无数遗传和表观遗传决定因素的新知识的获取传染病和其他给人类造成难以言喻痛苦的疾病。对此，大数据科学有望通过个性化、预测性、预防性和参与性医学来改善人类健康并预防疾病。因此，维持生物信息学核心的重要性怎么强调也不为过。期间 COBRE 第二阶段，生物信息学核心主要强调提供定制支持和合作服务，开发新的和改进的生物信息学工具，以及开展强化教育课程和实践培训研讨会。 COBRE 第三阶段的目标是促进生物信息学核心过渡到可持续状态 - 最先进的核心设施，能够支持新的、新兴的和重新出现的高水平研究传染病以及其他科学探究领域将通过以下方式实现：（1）加强和简化核心业务； (2) 扩大用户基础、能力、能力和范围并使其多样化；和（三）强化核心基础设施。对于目标 1，需求评估和用户满意度调查将旨在确保核心/用户界面和用户的核心操作的效率和有效性服务。对于目标 2，外展和营销活动将扩展到其他当地学术机构，夏威夷大学系统以外的生物技术公司和医院，并将与类似的公司建立强有力的合作伙伴关系位于其他 COBRE、INBRE 和 IDeA-CTR 计划中的核心，以进一步发展核心用户并使核心用户多样化基础并获得新的工具和技术。对于目标 3，制度化和分阶段的业务计划将在 COBRE 第三阶段期间开发，以利用校内和校外资源实现可持续性。预计生物信息学核心将实现上述每一个具体目标。一个强大的夏威夷大学系统总裁承诺全力支持生物信息学核心基础设施，未来五年内的专业职位和支持人员是更大战略计划的一部分将生物信息学制度化为网络基础设施部门的四大主要支柱之一。因此，我们有充分的理由乐观地认为，生物信息学核心将转变为全系统的应对大数据科学挑战的生物信息学资源。