Diabetes and Tuberculosis Pilot

糖尿病和结核病试点

• 批准号: 7525164
• 负责人: Adriana Perez
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7525164
• 关键词: Hispanic Americans; Mexican Americans; clinical research; community; comorbidity; disease /disorder proneness /risk; epidemiology; health disparity; high risk behavior /lifestyle; human subject; noninsulin dependent diabetes mellitus; socioeconomics; tuberculosis

Screening for Mycobacterium tuberculosis infection in those at high risk for developing clinical tuberculosis (TB) is a key strategy of the Centers for Disease Control and Prevention (CDC) to control the spread of TB in the US. This is particularly important at the US/Mexico border, where converging socioeconomic and demographic factors contribute to the higher burden of TB when compared to the US national average. This region also has high prevalence of type II diabetes (DB), which has long been known to predispose to active tuberculosis. Based on this information, we hypothesize that DB contributes to the burden of TB in the Hispanic population from four Texan counties along the Mexican-American border. Four counties in the Lower Rio Grande Valley (LRGV) will be analyzed in this pilot project: Hidalgo, Cameron, WilIacy and Starr. A secondary analysis of the Texas hospital discharges during 2001 will be implemented using ICD 9 codes for case and control selection. Unconditional multiple logistic regression analysis will be used to evaluate the relationship between tuberculosis and tentative associated factors. Health production functions will be estimated, using unconditional multiple logistic regression as well. The specific aims of the project are: Aim 1: Determine the degree of association of DB and TB in Hispanics in the LRGV Aim 2: Determine the strength of the association between TB and its associated risk factors (besides DB), with emphasis on underlying medical conditions. Aim 3: Estimate health production function that will identify relevant socio-economic indicators of TB and DB.

对临床结核病 (TB) 高危人群进行结核分枝杆菌感染筛查是美国疾病控制与预防中心 (CDC) 控制结核病在美国传播的一项关键策略。这在美国/墨西哥边境尤其重要，与美国全国平均水平相比，社会经济和人口因素的融合导致结核病负担更高。该地区的 II 型糖尿病 (DB) 患病率也很高，人们早就知道这种糖尿病容易患活动性结核病。根据这些信息，我们假设 DB 加重了墨西哥-美国边境沿线的四个德克萨斯县的西班牙裔人口的结核病负担。该试点项目将分析里奥格兰德河谷下游 (LRGV) 的四个县：伊达尔戈 (Hidalgo)、卡梅伦 (Cameron)、威利亚西 (WiIacy) 和 斯塔尔。将使用 ICD 9 代码进行病例和对照选择，对 2001 年德克萨斯州出院情况进行二次分析。将使用无条件多元逻辑回归分析来评估结核病与暂定相关因素之间的关系。还将使用无条件多元逻辑回归来估计健康生产函数。该项目的具体目标是： 目标 1：确定 LRGV 中西班牙裔 DB 和 TB 的关联程度 目标 2：确定结核病与其相关风险因素（除 DB 之外）之间的关联强度，重点关注潜在的医疗状况。 目标 3：估计健康生产函数，以确定结核病和结核病的相关社会经济指标。