BABOON RESEARCH RESOURCE PROGRAM

狒狒研究资源计划

• 批准号: 7392009
• 负责人: GARY L WHITE
• 金额: $ 108.26万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392009
• 关键词: BABOON; RESEARCH; RESOURCE; PROGRAM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): This P40 competitive renewal proposes to continue the aims of the initial grant application and expand the support of research investigators using baboons as models in biomedical and behavioral research. Not only have the investigators accomplished the aims of the initial grant proposal, but with the award of the R24 in July 2002 the investigators are now developing the SPF Baboon Resource. The OU Fort Reno Science Park Facility was completed in March of 2001 and became fully occupied by the summer of 2001. The facility provides four 0.5 acre outdoor corrals and eight large indoor gang cages for the group housing of baboons. The corrals are equipped with large climbing structures and concrete culverts. There is ample room for the large, multiple-male groups of baboons to exhibit species-typical behavior. Three adult males and from 25 to 30 adult female baboons with their infant and juvenile offspring populate each group. This social arrangement is typical for Papio (P.) anubis in the wild. The offspring remain in the corrals with their parents until they are needed for research. Many animals assigned to studies are later returned to their home corrals after the study period is completed. This scenario is characteristic of most vaccine protocols; baboons are removed in a group from a corral at Fort Reno, housed as a group at the Animal Resources Annex for the duration of the study, and then returned to as a group to the Fort Reno facility. The juveniles can remain together in the same corral until they reach puberty. The baboon colony has grown from 141 baboons at the outset of the P40 Grant support four years ago, to a colony of 284 baboons including 126 adult female baboons, 14 adult males, and 149 infants and juveniles. The investigators are presently housing 12 males, 115 adult females and their infant and juvenile offspring at the Fort Reno facility. During the last grant year, the investigators supplied 52 baboons to both OUHSC and outside research investigators. The investigators have published 18 articles and have supported National Institutes of Health (NIH) funded research programs at 12 outside intuitions during the last four years of the funding period. In order to accommodate increasing numbers of conventional baboons, the future plans include adding four new corrals to the present Fort Reno Facility. Additional plans include the construction of a separate, six-corral unit to house the SPF baboons. The investigators are adding two additional co-investigators who will expand the resource-based research. Uriel Blas-Machado, D.V.M., Ph.D., will characterize the parasitic protozoa Entamoeba (E.) histolytica that is endemic in the colony and in many colonies of baboons throughout the world. Dr. Blas-Machado will be assisted by the collaboration of Jonathan Ravdin, M.D., Chairman, Department of Medicine, University of Minnesota, College of Medicine. Dr. Ravdin is an expert in E. histolytica and has NIH funding to develop an oral vaccine for humans for protection from the organism. William A. Meier, D.V.M., Ph.D., Veterinary Pathologist at Oklahoma State University, will work with Dr. Ronald Kennedy and Dr. Christopher J. Miller, California National Primate Research Center, to develop reagents and methodologies to assess the cellular humoral and cellular immune response of baboons to infectious agents. The primary mission is to provide healthy and behaviorally normal baboons for biomedical and behavioral research to NIH-funded researchers at institutions across the United States. The investigators will offer the option of either selling baboons or leasing them for a use fee and ultimate return to the breeding colony.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。描述（由申请人提供）：本次 P40 竞争性更新提议继续最初拨款申请的目标，并扩大对使用狒狒作为生物医学和行为研究模型的研究人员的支持。研究人员不仅实现了最初拨款提案的目标，而且随着 2002 年 7 月 R24 的授予，研究人员现在正在开发 SPF 狒狒资源。 OU 雷诺堡科学园设施于 2001 年 3 月竣工，并于 2001 年夏季全面投入使用。该设施提供四个 0.5 英亩的室外畜栏和八个大型室内群笼，用于狒狒群居。畜栏配有大型攀爬结构和混凝土涵洞。有足够的空间让大型、多雄性狒狒群体表现出物种典型的行为。每组有 3 只成年雄性狒狒和 25 至 30 只成年雌性狒狒及其婴儿和青少年后代。这种社会安排是野生狒狒 (P.) anubis 的典型特征。后代与父母一起留在畜栏里，直到需要它们进行研究为止。许多被分配进行研究的动物在研究期结束后会被送回它们的畜栏。这种情况是大多数疫苗方案的特征；狒狒成群地从里诺堡的畜栏中移出，在研究期间成群地安置在动物资源附件中，然后成群地返回里诺堡设施。 青少年可以一起呆在同一个畜栏里，直到进入青春期。狒狒群落已从四年前 P40 拨款支持之初的 141 只狒狒增加到 284 只狒狒群，其中包括 126 只成年雌性狒狒、14 只成年雄性狒狒以及 149 只婴儿和青少年。调查人员目前在雷诺堡设施中安置了 12 名男性、115 名成年女性及其婴儿和青少年后代。在上一个资助年度，研究人员向 OUHSC 和外部研究人员提供了 52 只狒狒。研究人员发表了 18 篇文章，并在资助期限的最后四年中支持了美国国立卫生研究院 (NIH) 资助的 12 个外部机构的研究项目。为了容纳越来越多的传统狒狒，未来的计划包括在现有的里诺堡设施中增加四个新的畜栏。其他计划包括建造一个独立的六畜栏单元来容纳 SPF 狒狒。研究人员正在增加两名联合研究人员，他们将扩大基于资源的研究。 Uriel Blas-Machado，D.V.M.，Ph.D.，将描述寄生性原生动物溶组织内阿米巴 (E.) 的特征，这种原生动物在狒狒群体和世界各地的许多狒狒群体中流行。 Blas-Machado 博士将得到明尼苏达大学医学院医学系主任、医学博士 Jonathan Ravdin 的协助。 Ravdin 博士是溶组织内阿米巴方面的专家，并获得美国国立卫生研究院 (NIH) 的资助来开发人类口服疫苗，以免受该微生物的侵害。俄克拉荷马州立大学兽医病理学家 William A. Meier，D.V.M.，Ph.D. 将与加州国家灵长类研究中心的 Ronald Kennedy 博士和 Christopher J. Miller 博士合作，开发试剂和方法来评估细胞体液以及狒狒对传染源的细胞免疫反应。主要任务是为美国国立卫生研究院资助的美国各机构的研究人员提供健康且行为正常的狒狒，用于生物医学和行为研究。调查人员将提供出售狒狒或以收取使用费的方式租赁狒狒的选择，并最终返回繁殖地。