Specific Pathogen Free 18 Baboon Research Resource {(SPF18BRR): Resource Core

无特定病原体 18 狒狒研究资源 {(SPF18BRR)：资源核心

• 批准号: 10627137
• 负责人: Joe H. Simmons
• 金额: $ 121.41万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627137
• 关键词: Alzheimer' s disease related dementia; Animal Model; Animals; Area; Bacteremia; Bacterial Model; Biocompatible Materials; Biological; Biological Markers; Biology; Biomedical Research; Breeding; COVID-19 pneumonia; COVID-19 vaccine; Caregivers; Communities; Data; Data Management Resources; Databases; Development; Doctor of Philosophy; Family suidae; Female; Foundations; Future; General Population; Genetic; Genetic Engineering; Genetic Variation; Goals; Grant; Intramural Research Program; Lead; Modeling; Monitor; Online Systems; Papio; Papio anubis; Pertussis; Pharmacologic Substance; Play; Privatization; Production; Research; Research Contracts; Research Personnel; Research Project Grants; Research Support; Resources; Respiratory syncytial virus; Role; SARS-CoV-2 infection; Scientist; Services; Students; Training and Education; United States National Institutes of Health; Veterinarians; Virus; Work; Xenograft procedure; animal care; biobank; design; genetic analysis; genetic pedigree; genome sequencing; germ free condition; human model; improved; nonhuman primate; novel; offspring; pathogen; programs; searchable database; tool; web site; whole genome

PROJECT SUMMARY: RESOURCE COMPONENT The SPF18BRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPF18BRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPF18BRR has integrated a number of components into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPF18BRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of human respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next five years, the SPF18BRR will focus on expanding the SPF18 baboon breeding colony to meet current and future biomedical research needs for adventitious virus free olive baboons. The overall goals of the Resource Component of the SPF18BRR are to continue to expand and diversify the national research resource of SPF18 olive baboons and olive baboon derived biological materials; to provide education and training to scientists, veterinarians, colony managers, and animals caregivers who work with virus free baboons; and to support investigators who need facilities and expertise to conduct studies using SPF18 baboons. New areas of research continue to emerge that need SPF18 baboons: over the last few years alone the baboon has emerged as an excellent model of human Alzheimer’s disease and related dementias, and as an excellent model of human SARS CoV-2 infection. As these and other new areas of research develop, the SPF18BRR plays an essential role in providing animals, biological resources, and the expertise needed to support these research projects. Over the next five years, the SPF18BRR will continue to provide SPF18 baboons and related resources to the scientific community and will continue to increase the value of the SPF18 baboon as a model for biomedical research. Currently the demand for SPF18 baboons and biological resources far exceeds our ability to provide animals and resources to meet this need, which makes it imperative that NIH continue to support this unique biomedical research resource.

项目摘要：资源组件 SPF18BRR 是唯一国家级无外来病毒橄榄狒狒 (Papio anubis) 研究资源 可供 NIH 受资助者使用的联邦机构内部研究项目，包括 FDA、NSF 和 NIH；以及生物医学研究的其他赞助商（私人基金会、制药公司和 合同研究组织），SPF18BRR 中的狒狒在全世界绝对独一无二。 广泛的生物排除清单，包含通常在其他野生和圈养非人灵长类动物中发现的 18 种病原体 SPF18BRR 将许多组件集成到一个旨在满足需求的程序中。 在建议的支持期内，SPF18BRR 将继续使用。 改善其为用户提供的资源，并将继续添加有关生物学和 无病毒狒狒的研究价值狒狒仍然是重要的动物模型。 基因工程猪异种移植，是人类呼吸道合胞病毒的唯一NHP模型 和百日咳，它们仍然是细菌性败血症的一个非常重要的模型。 人类新冠肺炎相关肺炎的优秀模型，它们在开发 未来五年，SPF18BRR 将重点扩大针对 SARS CoV-2 的批准疫苗。 SPF18狒狒繁殖群体可满足当前和未来不定狒狒生物医学研究的需求 无病毒橄榄狒狒 SPF18BRR 资源部分的总体目标是继续 扩大 SPF18 橄榄狒狒和橄榄狒狒的国家研究资源并使其多样化 生物材料；为科学家、兽医、群体管理者提供教育和培训 与无病毒狒狒一起工作的动物护理人员；并为需要设施和服务的调查人员提供支持； 使用 SPF18 狒狒进行研究的专业知识不断出现，需要新的研究领域。 SPF18 狒狒：仅在过去几年里，狒狒已成为人类的优秀模型 阿尔茨海默病和相关痴呆症，并作为人类 SARS CoV-2 感染的优秀模型。 这些和其他新的研究领域的发展，SPF18BRR 在提供动物、 生物资源，以及支持这些研究项目所需的专业知识。 SPF18BRR将继续向科学界提供SPF18狒狒和相关资源 将继续提高 SPF18 狒狒作为生物医学研究模型的价值。 对 SPF18 狒狒和生物资源的需求远远超出了我们提供动物和资源的能力 为了满足这一需求，NIH 必须继续支持这一独特的生物医学研究 资源。