Specific Pathogen Free Baboon Research Resource (SPFBRR) - Bridge Funding Administrative Supplement

无特定病原体狒狒研究资源 (SPFBRR) - 过桥资助行政补充

• 批准号: 10596840
• 负责人: Joe H. Simmons
• 金额: $ 90万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10596840
• 关键词: Administrative Supplement; Alzheimer' s disease related dementia; Animal Experimentation; Animal Model; Animals; Bacteremia; Bacterial Model; Biocompatible Materials; Biology; Biomedical Research; Breeding; COVID-19 pneumonia; COVID-19 vaccine; Caregivers; Communities; Development; Discipline; Family suidae; Foundations; Funding; Future; Genetic Engineering; Goals; Grant; Health Sciences; Immunobiology; Intramural Research Program; Maintenance; Modeling; Oklahoma; Papio; Papio anubis; Pertussis; Pharmacologic Substance; Privatization; Production; Research; Research Contracts; Research Personnel; Resources; Respiratory syncytial virus; Scientist; Services; Tissues; Training; Training and Education; United States National Institutes of Health; Universities; Virus; Work; Xenograft procedure; design; germ free condition; human model; improved; nonhuman primate; pathogen; programs; training opportunity; virus resource; web site

PROJECT SUMMARY This application is a request for bridge funding for the “Specific Pathogen Free Baboon Research Resource” (SPFBRR) P40 OD024628. The SPFBRR was founded with NIH support at the University of Oklahoma Health Sciences Center (OUHSC) in 2002 and was relocated to the Keeling Center in 2017. The SPFBRR has received continuous NIH support since it was founded. The SPFBRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPFBRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPFBRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPFBRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next year the SPFBRR will focus on maintaining the SPF18 baboon breeding colony to meet current and future biomedical research needs. The overall goal of the SPFBRR is to provide a national research resource of virus free olive baboons; provide baboon derived biological materials; provide education and training opportunities to scientist, colony managers, and animal caregivers who want to work with baboons; and to provide investigators with facilities and expertise to conduct studies using virus free baboons.

项目摘要 该应用程序是为“特定病原体无病原体研究的桥梁资金的请求 资源”（SPFBRR）P40 OD024628。SPFBRR在大学的NIH支持下建立 俄克拉荷马州卫生科学中心（OUHSC）于2002年，于2017年搬迁到基林中心。 SPFBRR自成立以来就获得了连续的NIH支持。 SPFBRR是唯一的国家 NIH授予者可用的先进病毒无病毒狒狒（Papio Anubis）的研究资源； 联邦机构的壁内研究计划，包括FDA，NSF和NIH；和其他赞助商 生物医学研究（私人基金会，制药公司和合同研究组织）。 SPFBRR中的狒狒在全世界绝对独特 病原体通常在其他野生和俘虏的非人类灵长类动物殖民地中发现。 SPFBRR具有 将多个学科整合到一个计划中，旨在满足调查人员的需求 资源。在拟议的支持期间，SPFBRR将继续改善其资源 提供给用户，并将继续添加有关无病毒生物学和研究价值的新信息 狒狒的网站。狒狒仍然是基因工程猪的重要动物模型 异种移植是唯一的NHP呼吸综合病毒和百日咳模型，它们是 仍然是细菌败血症的非常重要的模型。此外，狒狒是人类的出色模型 共同相关的肺炎，它们有助于开发批准的疫苗 SARS-CoV-2。明年，SPFBRR将专注于维持SPF18狒狒繁殖殖民地 满足当前和未来的生物医学研究需求。 SPFBRR的总体目标是提供 国家研究资源的无病毒狒狒；提供狒狒衍生的生物材料； 向科学家，殖民地经理和动物护理人员提供教育和培训机会 想要与狒狒一起工作的人；并为调查人员提供设施和专业知识以进行 使用无病毒狒狒的研究。