Electrophysiological Probes And Treatments In Neurobehav

神经行为的电生理学探针和治疗

• 批准号: 6990706
• 负责人: Eric M Wassermann
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6990706
• 关键词: behavioral /social science research tag; brain electronic stimulator; clinical research; cognition; dementia; electrophysiology; frontal lobe /cortex; human subject; human therapy evaluation; learning; motor cortex; neurophysiology; neuropsychological tests; neuropsychology; patient oriented research; psychotherapy; temporal lobe /cortex; transcranial magnetic stimulation

Low-intensity DC polarization of focal cortical areas is known to alter the function of neurons in animals and humans. We are investigating the properties of this kind of brain stimulation and testing its ability to alter cognitive function in healthy subjects. We have completed a large Phase I, sham-controlled trial of DC polarization of the left prefrontal area in healthy volunteers. Results show safety even at higher intensities than those used in published modern studies and we also found a significant facilitation of word list generation with anodal current relative to sham and cathodal current. Currently, we are also testing a similar anodal current treatment for impaired fluency in patients with frontotemporal dementia. These are the first studies of their kind and the first modern human use of DC polarization in this country.

已知局灶性皮质区域的低强度DC极化会改变动物和人类神经元的功能。我们正在研究这种大脑刺激的特性，并测试其改变健康受试者认知功能的能力。我们已经完成了健康志愿者左前额叶区域DC极化的一项大型I期，假对照的试验。结果表明，与已发表的现代研究相比，在更高的强度下，安全性甚至更高，我们还发现，相对于假和阴极电流，具有阳极电流的单词清单产生的显着促进。目前，我们还在测试类似的阳极电流治疗，以使额颞痴呆患者的流利程度受损。这些是对同类的第一批研究，也是该国DC两极分化的首次现代人类使用。