Electrophysiological Probes And Treatments In Neurobehavioral Disorders

神经行为障碍的电生理学探针和治疗

• 批准号: 7594681
• 负责人: Eric M Wassermann
• 金额: $ 53.5万
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7594681
• 关键词: Area; Behavior Disorders; Behavioral; Brain; Characteristics; Decision Making; Dopamine; Emotions; End Point; Generations; Genetic Variation; Goals; Individual; Institutes; Learning; Link; Measurement; Memory; Mind; Motor Cortex; Muscle; New Mexico; Parkinson Disease; Patients; Pharmaceutical Preparations; Research Personnel; Rewards; Stimulus; Techniques; Testing; Time; Transcranial magnetic stimulation; Universities; Work; base; environmental change; frontal lobe; neurobehavioral disorder; neuroimaging; neurophysiology; novel; programs; research study; response; trait

Treatment studies We are currently engaged in testing the ability of transcranial direct current brain polarization to modulate frontal lobe activity. Ongoing studies in this area are on (1) emotion-based decision making and response to arousing stimuli and (2) enhancing verbal memory and other forms of learning. Neurophysiological probe studies We have successfully shown changes in the motor cortex response to transcranial magnetic stimulation that are linked to the expecting and receiving money reward. This is the first demonstration of reward related activity in the motor cortex and links the motor cortex conceptually with other frontal areas involved in response generation and selection. We will go on to test the dopamine contribution to this phenomenon by repeating the experiment in patients with Parkinson disease on and off medication. Collaborative work With support from a DARPA program on accelerated learning, we are collaborating with investigators at the MIND Institute at the University of New Mexico on using DC brain polarization to shorten the time required to attain behavioral and neuroimaging endpoints for expert status on threat recognition tasks.

治疗研究 目前，我们正在测试经颅直流脑极化调节额叶活动的能力。 该领域正在进行的研究正在（1）基于情绪的决策和对引起刺激的反应以及（2）增强言语记忆和其他形式的学习。 神经生理探测研究 我们已经成功地显示了与经颅磁刺激的运动皮层响应的变化，这与预期和获得货币奖励有关。 这是运动皮层中奖励相关活动的首次演示，并将运动皮层与响应产生和选择中有关的其他额叶区域联系起来。 我们将通过重复药物帕金森病患者的实验来测试多巴胺对该现象的贡献。 协作工作 在DARPA的加速学习计划的支持下，我们正在与新墨西哥大学思维学院的调查人员合作，利用DC大脑极化来缩短在威胁识别任务上获得专家状态的行为和神经影像学终点所需的时间。