Cognitive functioning following deep brain stimulation

深部脑刺激后的认知功能

• 批准号: 6738165
• 负责人: Michele Klaswick York
• 金额: $ 16.8万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6738165
• 关键词: Parkinson' s disease; behavioral /social science research tag; brain electronic stimulator; clinical trials; cognition; cues; electrodes; frontal lobe /cortex; human subject; human therapy evaluation; lenticular nucleus; magnetic resonance imaging; nervous system disorder therapy; neural information processing; neuroanatomy; neuropsychological tests; neuropsychology; neurosurgery; patient oriented research; performance; postoperative state; quality of life; semantics; short term memory; speech; subthalamus

DESCRIPTION (provided by the applicant): Dr. Michele York, under the mentorship of Dr. Harvey Levin, Director of Research of Baylor College of Medicine's (BCM) Physical Medicine and Rehabilitation Department and Professor of Psychiatry and Neurosurgery, and Dr. Robert Grossman, the Chairman of BCM's Neurosurgery Department, will more effectively evaluate the long-term cognitive effects of deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD). The scientific objective of the proposed research plan is to more clearly understand the relationship between the frontostriatal neural circuitry affected by DBS and PD and cognitive functioning. The clinical objectives of the proposed research plan include improving upon the evaluation of outcome by improving cognitive diagnostic techniques, clarifying the clinical criteria for surgical selection, and incorporating analysis of post-operative magnetic resonance imaging (MRI) findings. To achieve these aims, Dr. York will compare the executive functioning of patients undergoing staged bilateral subthalamic (STN) and globus pallidus (GPI) DEIS to patients who receive the best medical management for the treatment of PD on verbal fluency measures administered under conditions of set shifting and attentional control and working memory measures, which are cognitive processes dependent on the functional integrity of frontostriatal circuitry. The relationship between DBS electrode placement and performance on these frontostriatal neuropsychological tasks will also be investigated. The objectives of the training program are to acquire practical and technical skills that will aid Dr. York in developing her career, specifically in the areas of neurosurgical interventions and neurological evaluations of PD, structural and functional neuroimaging, and the neuroscience of PD. This training will provide Dr. York with a better understanding of the cognitive deficits in PD and the mechanisms and consequences of emerging interventions for the treatment of this neurological disease. The training activities during the award period will consist of 3 major components: 1) Didactics through coursework, technical training seminars, rounds, and observation, 2) Supervisory Guidance through regularly scheduled meetings with mentors and an Advisory Committee, and 3) Instruction in the Responsible Conduct of Research. Dr. York will gain the necessary knowledge to attain her long-term career goal of working as an independent clinical researcher by acquiring the background and skills in neuroscience, neuroimaging, and grant preparation needed to write a ROI proposal to adapt these cognitive tasks to a functional imaging setting to further elucidate the neural mechanisms of PD and DBS.

描述（申请人提供）：Michele York博士，在指导下 贝勒医学院研究主任Harvey Levin博士（BCM） 物理医学和康复部，精神病学教授和 神经外科和BCM神经外科主席Robert Grossman博士 部门将更有效地评估 深脑刺激（DBS）治疗帕金森氏病（PD）。这 拟议的研究计划的科学目标是更清楚 了解额叶神经回路之间的关系 受DB和PD的影响以及认知功能。临床目标的 拟议的研究计划包括改善评估结果的评估 提高认知诊断技术，阐明临床标准 手术选择，并结合术后磁性的分析 共振成像（MRI）发现。为了实现这些目标，约克博士将比较 接受分期双侧下丘脑的患者的执行功能 （STN）和Globus Pallidus（GPI）DEIS接受接受最好的医疗的患者 管理PD在口头流利度措施上的治疗 在设定转移，注意力控制和工作记忆的条件下 措施，这是依赖功能完整性的认知过程 额叶电路。 DBS电极放置之间的关系 以及这些额叶神经心理学任务的表现也将是 调查。培训计划的目标是获得实用 以及将帮助约克博士发展职业的技术技能， 特别是在神经外科干预和神经系统领域 对PD，结构和功能神经影像的评估以及神经科学 PD。这项培训将使约克博士更好地了解 PD的认知缺陷以及出现的机制和后果 治疗这种神经系统疾病的干预措施。培训 奖励期间的活动将包括3个主要组成部分：1） 通过课程工作，技术培训研讨会，回合和 观察，2）通过定期安排的会议与 导师和咨询委员会，以及3）负责任的指导 进行研究。约克博士将获得必要的知识来实现​​她 长期职业目标是作为独立临床研究人员的工作 获得神经科学，神经影像学和授予的背景和技能 需要编写ROI建议需要准备这些认知任务 功能成像设置以进一步阐明PD的神经机制 DBS。