Cortical Distinctions in Visual and Auditory Naming

视觉和听觉命名的皮质区别

基本信息

批准号：
6951135
负责人：
SANDRA SERAFINI
金额：
$ 4.73万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-16 至 2005-09-15
项目状态：
已结题

项目摘要

DESCRIPTION (Verbatim from applicant?s abstract): It is well established that word finding tasks can predict performance in several measures of expressive speech, and that deficits in word finding are considered sensitive to language deficits in several types of aphasia. Conventional measures of word finding are currently almost exclusively comprised of visual confrontation naming tasks, which have been shown to have limited accuracy and may not reflect abilities or deficits in auditory word finding. When resecting pathological tissue in the brain, one goal of the neurosurgeon is to assess and identify not only the boundaries of pathological tissue, but to identify the location of functional cortex that is dedicated to language processing in order that it be spared. The long term objective of this proposal is to combine standard (visual) and novel (auditory) word finding paradigms that will provide neurosurgeons with a more complete language localization map from which to decide resection margins that spare eloquent cortex. Specifically, this project proposes to develop an auditory object naming paradigm to examine regional distinctions between visual and auditory object naming in both the fMRI and the intraoperative cortical stimulation setting for patients with temporal lobe epilepsy. A method for utilizing a frameless stereotaxy system to accurately co-register the brain across the two techniques will be developed and implemented to monitor the reliability of using fMRI as a non-invasive pre-surgical language localization technique.

描述（申请人的摘要的逐字化）：已经确定，单词查找任务可以预测表达性语音的几种措施中的表现，并且单词发现中的缺陷被认为对几种类型的失语症中的语言缺陷敏感。目前，传统的单词查找措施几乎完全由视觉对抗组成命名任务已被证明具有有限的准确性，并且可能无法反映听觉单词查找中的能力或缺陷。当切除大脑中的病理组织时，神经外科医生的一个目标不仅是评估和识别病理组织的边界，而且要确定专用于语言处理的功能性皮质的位置，以使其幸免。该建议的长期目标是结合标准（视觉）和新颖（听觉）单词查找范式，这些范式将为神经外科医生提供更完整的语言本地化图可以从中决定避免雄辩的皮质的切除边距。具体而言，该项目提议开发一个听觉对象命名范式，以检查fMRI中的视觉和听觉对象与颞叶癫痫患者命名的视觉和听觉对象命名。一种方法将利用无框立体定位系统准确地在这两种技术上共同注册大脑，以监视将fMRI用作非侵入性的术前语言本地化技术的可靠性。