Matrix-Addressable X-ray Source for Medical Imaging

用于医学成像的矩阵可寻址 X 射线源

• 批准号: 6915060
• 负责人: PAUL R SCHWOEBEL
• 金额: $ 22.82万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6915060
• 关键词: X ray; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; radiography

DESCRIPTION (provided by applicant): We propose to develop a new x-ray source for medical research and diagnostic applications. The development of this source could radically change the use of x-rays in areas ranging from digital tomosynthesis to computed tomography (CT). The proposed source is a high-bandwidth, matrixaddressable array of individual cold-cathode x-ray point sources that can be made to cover areas of roughly one square millimeter to several square meters. This flat panel x-ray source could be used to construct, for example, compact, flat-panel-based tomography systems for use in the field, laboratory, and rural clinic. The objective of the proposed research is to validate the operation of the flat panel x-ray source by demonstrating a functional prototype. The specific aims of this 2-year research program are to: (1) design, build, and characterize a prototype x-ray source and (2) demonstrate source operation with conventional xray radiographs and quantify source performance using standard image assessment techniques. Following the successful completion of this program we will apply for a follow-on grant to continue the refinement and development of the x-ray source. This research will involve more detailed studies of image assessment combined with further quantification of how various source preparation and operating parameters influence the x-ray panel source's output, reproducibility, and lifetime.

描述（由申请人提供）： 我们建议开发一种用于医学研究和诊断应用的新型 X 射线源。该源的开发可能会从根本上改变 X 射线在从数字断层合成到计算机断层扫描 (CT) 等领域的使用。所提出的源是一个高带宽、矩阵可寻址的单个冷阴极 X 射线点源阵列，可以覆盖大约一平方毫米到几平方米的区域。例如，该平板 X 射线源可用于构建紧凑型平板断层扫描系统，以供现场、实验室和农村诊所使用。 本研究的目的是通过演示功能原型来验证平板 X 射线源的运行。这个为期 2 年的研究计划的具体目标是：(1) 设计、构建和表征原型 X 射线源，(2) 使用传统 X 射线射线照片演示源操作，并使用标准图像评估技术量化源性能。 该计划成功完成后，我们将申请后续拨款，以继续完善和开发 X 射线源。这项研究将涉及更详细的图像评估研究，并进一步量化各种源准备和操作参数如何影响 X 射线面板源的输出、再现性和寿命。