Matrix-Addressable X-ray Source for Medical Imaging

用于医学成像的矩阵可寻址 X 射线源

• 批准号: 6915060
• 负责人: PAUL R SCHWOEBEL
• 金额: $ 22.82万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6915060
• 关键词: X ray; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; radiography

DESCRIPTION (provided by applicant): We propose to develop a new x-ray source for medical research and diagnostic applications. The development of this source could radically change the use of x-rays in areas ranging from digital tomosynthesis to computed tomography (CT). The proposed source is a high-bandwidth, matrixaddressable array of individual cold-cathode x-ray point sources that can be made to cover areas of roughly one square millimeter to several square meters. This flat panel x-ray source could be used to construct, for example, compact, flat-panel-based tomography systems for use in the field, laboratory, and rural clinic. The objective of the proposed research is to validate the operation of the flat panel x-ray source by demonstrating a functional prototype. The specific aims of this 2-year research program are to: (1) design, build, and characterize a prototype x-ray source and (2) demonstrate source operation with conventional xray radiographs and quantify source performance using standard image assessment techniques. Following the successful completion of this program we will apply for a follow-on grant to continue the refinement and development of the x-ray source. This research will involve more detailed studies of image assessment combined with further quantification of how various source preparation and operating parameters influence the x-ray panel source's output, reproducibility, and lifetime.

描述（由申请人提供）： 我们建议为医学研究和诊断应用开发新的X射线源。该来源的开发可以从根本上改变X射线的使用，从数字间隔到计算机断层扫描（CT）。所提出的来源是单个感冒X射线点源的高带宽，可基质添加的阵列，可以覆盖大约一平方英毫米至几平方米的区域。该平板X射线源可用于构建，例如，用于现场，实验室和农村诊所的紧凑，基于平板的层析成像系统。 拟议的研究的目的是通过证明功能原型来验证平板X射线源的运行。这项为期两年研究计划的具体目的是：（1）设计，构建和表征X射线原型的原型，（2）使用常规X射线照相仪展示源操作，并使用标准图像评估技术量化源性能。 成功完成该计划后，我们将申请一项后续赠款，以继续进行X射线源的完善和开发。这项研究将涉及对图像评估的更详细的研究，并进一步量化各种源制备和操作参数如何影响X射线面板源的输出，可重复性和寿命。