A 2D Stationary X-ray Source System for Improved Breast Tomosynthesis Imaging

用于改进乳腺断层合成成像的 2D 固定 X 射线源系统

• 批准号: 10687768
• 负责人: PAUL R SCHWOEBEL
• 金额: $ 43.08万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-15 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10687768
• 关键词: Anodes; Applications Grants; Breast; Calibration; California; Caring; Cathodes; Characteristics; Clinical; Clinical Trials; Collimator; Digital Breast Tomosynthesis; Dimensions; Electronics; Elements; Filament; Film; Frequencies; Image; Imaging technology; Individual; International; Mammography; Mechanics; Modeling; Morphologic artifacts; Motion; New Mexico; Output; Patients; Performance; Persons; Protocols documentation; Research; Roentgen Rays; Scanning; Source; Spottings; Structure; System; Technology; Time; Translations; Tungsten; Universities; X-Ray Medical Imaging; base; cost; deep learning; design; detector; experimental study; improved; industry partner; interest; meetings; professor; programs; prototype; reconstruction; simulation; success; tomography; tomosynthesis; two-dimensional

PROJECT SUMMARY/ABSTRACT This grant application proposes to use the unique stationary Multi-X-ray-source Array (MXA) technology developed and applied to digital breast tomosynthesis (DBT) under our current R01 to: 1) significantly improve DBT image quality by extending the MXA technology to produce a clinically practical two-dimensional (2D) MXA and 2) demonstrate a capable and fully characterized 2D MXA DBT system to use for clinical trials under a follow-on R01 Academic–Industrial Partnership program. By the time the first film-based commercial tomosynthesis systems were developed in the 1970s, it was realized that 2D motion of the X-ray source significantly improved image quality relative to 1D motion due to better blurring of the shadows of structures both above and below the plane of interest. All existing commercial DBT systems use 1D motion because 2D mechanical motion is complicated and expensive and would significantly increase scan times which are already too long at 4 to 25 s with the 1D motion-based systems. Compare this to mammography, where it is preferred to keep scan times under 2 s to minimize patient-motion artifacts. Extending MXA technology to make 2D breast tomosynthesis practical – by meeting scan time constraints – will provide superior performance compared with all commercial breast tomosynthesis systems on the market today, while at the same time decreasing system size and cost. The net result would be a significant increase in the capability of DBT systems and a broadening of their availability to bring better care to more people sooner. The Specific Aims of this application are: Aim 1. Use modeling and experiments to design the 2D MXA-DBT prototype system Aim 2. Build 2D MXA DBT prototype system Aim 3. Evaluate performance of 2D MXA DBT prototype system

项目摘要/摘要 这份赠款申请提案使用唯一的固定多X射线源阵列（MXA）技术 在我们当前的R01下开发并应用于数字乳房合成（DBT）：1）显着改善 通过扩展MXA技术来生产临床实用的二维（2D）MXA，DBT图像质量 2）展示了一个能干且完全表征的2D MXA DBT系统，用于在A下用于临床试验 后续R01学术工业合作计划。 到1970年代开发了第一个基于电影的商业性质合成系统时， 意识到X射线源的2D运动相对于由于1D运动而显着提高了图像质量 更好地模糊了感兴趣平面上方和下方的结构的阴影。所有现有的广告 DBT系统使用1D运动，因为2D机械运动复杂且昂贵，并且会显着 使用基于1D运动的系统在4至25 s时增加扫描时间已经太长了。比较这个 乳房X线摄影，首选将扫描时间保持在2 s以下以最大程度地减少患者运动伪像。 扩展MXA技术以使2D乳房合成合成实用 - 通过满足扫描时间限制 - 与市场上所有商业乳房合成系统相比，将提供卓越的性能 如今，同时降低了系统规模和成本。最终结果将大大增加 在DBT系统的能力以及扩大其可用性的范围内，可以为更多的人带来更好的护理 更早。 本应用程序的具体目的是： 目标1。使用建模和实验设计2D MXA-DBT原型系统 目标2。构建2D MXA DBT原型系统 目标3。评估2D MXA DBT原型系统的性能