Real-Time Tomosynthesis Imaging for Vascular Dynamics

用于血管动力学的实时断层合成成像

基本信息

批准号：
7738545
负责人：
PAUL R SCHWOEBEL
金额：
$ 20.04万
依托单位：
SRI INTERNATIONAL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-15 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7738545
关键词：
Air Animals Area Arts Blood Vessels Blood Volume Blood flow Breast Capillary Permeability Characteristics Clinics and Hospitals Contrast Media Coupled Data Set Development Devices Diagnosis Elements Engineering Evaluation Frequencies Functional Imaging Health Services Research Human Image Imaging technology Injection of therapeutic agent Laboratories Lead Malignant Neoplasms Measurement Measures Medical Imaging Metric Modeling Monitor Motion Pictures Mus Noise Operative Surgical Procedures Output Performance Perfusion Pharmaceutical Preparations Physiological Property Qualifying Radiation therapy Rattus Research Personnel Resolution Risk Signal Transduction Source Speed Spottings Stratification System Techniques Technology Therapeutic Therapeutic Effect Time Tissues Tomography, Computed, Scanners Vascular Permeabilities Vascular System Work X-Ray Computed Tomography angiogenesis base chemotherapeutic agent cost design detector digital human disease improved in vivo novel public health relevance quantum response rural area tomography tumor growth

项目摘要

DESCRIPTION (provided by applicant): Physiological characteristics of malignant tumors such as blood flow and vascular permeability are strongly coupled to therapeutic effects. Tomographic vascular dynamic information is of enormous utility in monitoring tumor growth and vessel recruitment, as well as in assessing the therapeutic response of novel chemotherapeutic agents. We propose to develop a real-time tomosynthesis (TS) system to image vascular dynamics by integrating novel stationary x-ray source array technology with an existing flat-panel detector. The system will be suitable for vascular studies in modestly sized objects such as human breasts or small animals, particularly mice and rats because they are widely used for models of human diseases, including cancer. The dynamic imaging system will provide time-resolved tomographic images. After we design, fabricate, and qualify the system, we will evaluate it using phantoms to acquire real-time tomographic image data sets. These data sets will provide important information to guide the further engineering development of the stationary x-ray source technology and real-time TS system. The specific aims of this R21 proposal are to: Aim 1. Construct a real-time multi-source tomographic imaging system for vascular analysis (Year 1) Aim 2. Demonstrate stationary source operation and quantify system temporal and spatial performance using phantoms and state-of-the-art image assessment techniques. (Year 2) The stationary x-ray source proposed for demonstration in this proposal could significantly impact other areas of medical imaging technology. The potential for increased imaging speed and the implementation of novel acquisition geometries imparted by such sources could lead to the development of compact, affordable CT and digital TS systems for use in hospitals, clinics, rural areas, and laboratories, and thereby benefit both the medical care and research fields. PUBLIC HEALTH RELEVANCE: We propose to significantly improve medical imaging technology by developing an x-ray imaging system that will allow cancer researchers to take three-dimensional x-ray motion pictures. The potential for increased imaging speed, reduced system cost, and the implementation of novel acquisition geometries imparted by such a device could lead to the development of compact, affordable CT and digital tomosynthesis systems for use in hospitals, clinics, rural areas, and laboratories, and thereby benefit both the medical care and research fields.

描述（由申请人提供）：恶性肿瘤（如血流和血管通透性）的生理特征与治疗作用密切相关。层析成像血管动态信息在监测肿瘤生长和血管募集以及评估新型化学治疗剂的治疗反应方面具有巨大的实用性。我们建议通过将新型的固定X射线源阵列技术与现有的平板检测器整合在一起，以开发实时的质合成系统（TS）系统来图像血管动力学。该系统适用于适度大小的物体（例如人类乳房或小动物）（尤其是小鼠和大鼠）的血管研究，因为它们被广泛用于包括癌症在内的人类疾病模型。动态成像系统将提供时间分辨的层析成像图像。在设计，制造和限定系统之后，我们将使用幻影对其进行评估以获取实时层析成像图像数据集。这些数据集将提供重要的信息，以指导固定X射线源技术和实时TS系统的进一步工程开发。该R21提案的具体目的是：AIM 1。构建一种用于血管分析的实时多源层析成像系统（第1年）目标2。证明使用幻影和状态 - 图像评估技术。（第2年）在此提案中提出的固定X射线源可能会严重影响医学成像技术的其他领域。提高成像速度的潜力以及这种来源赋予新颖的收购几何形状的实施可能会导致在医院，诊所，农村地区和实验室中使用紧凑，负担得起的CT和数字TS系统的发展，从而使医疗护理和研究领域。公共卫生相关性：我们建议通过开发X射线成像系统来显着改善医学成像技术，该系统将使癌症研究人员能够拍摄三维X射线电影。这种设备赋予成像速度，系统成本降低以及实施新的采集几何形状的潜力可能会导致紧凑，负担得起的CT和数字合成系统的发展，用于医院，诊所，农村地区和实验室，以及因此，受益于医疗和研究领域。