Inhaled Aerosol Dosimetry: Advances, Applications, and Impacts on Risk Assessments and Therapeutics

吸入气溶胶剂量测定：进展、应用以及对风险评估和治疗的影响

• 批准号: 10752525
• 负责人: Robert Phalen
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10752525
• 关键词: Aerosols; Air; Air Pollution; Animals; Applied Research; Area; Atmosphere; Award; Awareness; Basic Science; Budgets; COVID-19 pandemic; Case Study; Collaborations; Communication; Complex Mixtures; Computer Models; Computers; Creativeness; Deposition; Diagnosis; Discipline; Disease; Dose; Engineering; Environment; Event; Fees; Gases; Gender; Government; Health; In Vitro; Individual Differences; Inhalation; Injury; International; Journals; Laboratories; Literature; Lung; Malignant Neoplasms; Medical; Medicine; Metabolism; Methods; National Heart, Lung, and Blood Institute; Occupational; Occupations; Paper; Peer Review; Physicians; Postdoctoral Fellow; Privatization; Publishing; Request for Proposals; Research; Research Personnel; Risk; Risk Assessment; Science; Scientist; Solid; Specialist; Students; Therapeutic; Thinking; Time; Tissues; Transportation; Underrepresented Minority; Underrepresented Populations; United States National Academy of Sciences; Universities; Update; Vaccines; Viral; Woman; Workplace; career; doctoral student; dosimetry; frontier; medical schools; medical specialties; meetings; men; minority scientist; multidisciplinary; particle; posters; prevent; programs; prospective; racial disparity; symposium; transmission process; Aerosols; Air; Air Pollution; Animals; Applied Research; Area; Atmosphere; Award; Awareness; Basic Science; Budgets; COVID-19 pandemic; Case Study; Collaborations; Communication; Complex Mixtures; Computer Models; Computers; Creativeness; Deposition; Diagnosis; Discipline; Disease; Dose; Engineering; Environment; Event; Fees; Gases; Gender; Government; Health; In Vitro; Individual Differences; Inhalation; Injury; International; Journals; Laboratories; Literature; Lung; Malignant Neoplasms; Medical; Medicine; Metabolism; Methods; National Heart, Lung, and Blood Institute; Occupational; Occupations; Paper; Peer Review; Physicians; Postdoctoral Fellow; Privatization; Publishing; Request for Proposals; Research; Research Personnel; Risk; Risk Assessment; Science; Scientist; Solid; Specialist; Students; Therapeutic; Thinking; Time; Tissues; Transportation; Underrepresented Minority; Underrepresented Populations; United States National Academy of Sciences; Universities; Update; Vaccines; Viral; Woman; Workplace; career; doctoral student; dosimetry; frontier; medical schools; medical specialties; meetings; men; minority scientist; multidisciplinary; particle; posters; prevent; programs; prospective; racial disparity; symposium; transmission process

PROJECT SUMMARY/ABSTRACT The COVID-19 pandemic exposed a critical lack of our understanding the airborne transmission of infectious viral agents. Deficiencies in understanding the deposition, metabolism, distribution in the body, and mechanisms of injury of aerosols (particles suspended in a gas) limit the confidence in setting air quality standards and developing new inhaled therapeutics. The delivered inhaled dose (e.g., mg/target tissues) is poorly understood due to individual differences, the complexity of aerosols, and post inhalation internal events. UC Irvine’s Air Pollution Health Effects Laboratory has been involved in basic and applied research in this area since its founding in the School of Medicine in 1974. It has initiated several topic-focused multi-disciplinary conferences on inhaled aerosols. This proposal requests support for an international conference “Inhaled Aerosol Dosimetry: Advances, Applications and Impacts on Risk Assessments and Therapeutics”, to be held adjacent to the UC Irvine campus at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering, in Irvine, CA 3 days in October of 2024. The conference center offers solid support including an atmosphere conducive to collegiality, inclusion, and creative thinking. The conference will bring together scientists, engineers, medical researchers, regulators, and others who normally attend separate professional meetings, and read specialty journals in relative isolation thereby inhibiting cross-discipline communications and collaborations. Our Organizing Committee of 10 men and 7 women scientists represents universities, governments, and private laboratories. They are aware of critical research needs in medicine, science, and government, as well as gender and racial inequalities. Sessions include; overviews, recent research, complex mixtures; in-vitro methods to reduce the use of live animals; computer model advances; and case studies. Each session is plenary, geared to be understandable by all attendees, and each has discussion time. The program supports cross-discipline communication and collaboration. The registration fee will cover all sessions, and transportation between the nearby airport (SNA), the hotels, and the conference center. Staff will help those with special needs and efforts will be made to attract those from underrepresented groups. Students will have a luncheon with prospective employers, and awards will be made for outstanding student posters. A Proceedings will be published, and a journal issue is planned for those papers that meet peer review standards. Startup support is provided by our University. The total budget is about $155,000, and $25,000 is requested from the NHLBI to help support staff and students, and attract attendees from underrepresented groups. Revised 11-26-2022

项目摘要/摘要 COVID-19大流行使我们理解传染性病毒药物的空中传播危机不足。 理解沉积，代谢，体内分布和气溶胶损伤机制的缺陷 （悬浮在气体中的颗粒）限制了设定空气质量标准和开发新继承的信心 治疗。由于个体差异，交付的内部剂量（例如，mg/目标时间）对 气溶胶的复杂性和吸入后内部事件。 UC Irvine的空气污染健康效应实验室已经 自1974年在医学院成立以来，它参与了该领域的基础研究和应用研究。 几个以主题为中心的多学科会议在继承的气溶胶上举行。该建议要求支持 国际会议“吸入气溶胶剂量法：风险评估的进步，应用和影响 疗法”，将与国家国家的阿诺德和马贝尔·贝克曼中心相邻。 2024年10月3天在欧文的科学与工程学院 支持包括对合作，包容性和创造性思维的气氛。会议将带来 科学家，工程师，医学研究人员，监管机构以及其他通常参加专业人士的其他人 会议，并以相对隔离阅读专业期刊，从而抑制跨学科的通信和 协作。我们由10名男性和7位女科学家组成的组织委员会代表大学，政府和 私人实验室。他们意识到医学，科学和政府的关键研究需求以及性别 和种族不平等。会议包括；概述，最近的研究，复杂的混合物；消极的方法来减少 使用活动物；计算机模型进步；和案例研究。每个会议都是全体会议，旨在理解 所有与会者都有讨论时间。该计划支持跨学科的沟通和协作。 注册费将涵盖所有会议，并在附近的机场（SNA），酒店和 会议中心。员工将帮助有特殊需要的人，并努力吸引那些 代表性不足的群体。学生将与潜在雇主共进午餐，并将为 出色的学生海报。将发布诉讼程序，并计划针对那些符合的论文发行期刊问题 同行评审标准。启动支持由我们的大学提供。总预算约为15.5万美元，25,000美元是 向NHLBI的要求，以帮助支持员工和学生，以及来自代表性不足的团体的吸引力参与者。 修订了11-26-2022