Inhaled Aerosol Dosimetry: Advances, Applications, and Impacts on Risk Assessments and Therapeutics

吸入气溶胶剂量测定：进展、应用以及对风险评估和治疗的影响

• 批准号: 10752525
• 负责人: Robert Phalen
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10752525
• 关键词: Aerosols; Air; Air Pollution; Animals; Applied Research; Area; Atmosphere; Award; Awareness; Basic Science; Budgets; COVID-19 pandemic; Case Study; Collaborations; Communication; Complex Mixtures; Computer Models; Computers; Creativeness; Deposition; Diagnosis; Discipline; Disease; Dose; Engineering; Environment; Event; Fees; Gases; Gender; Government; Health; In Vitro; Individual Differences; Inhalation; Injury; International; Journals; Laboratories; Literature; Lung; Malignant Neoplasms; Medical; Medicine; Metabolism; Methods; National Heart, Lung, and Blood Institute; Occupational; Occupations; Paper; Peer Review; Physicians; Postdoctoral Fellow; Privatization; Publishing; Request for Proposals; Research; Research Personnel; Risk; Risk Assessment; Science; Scientist; Solid; Specialist; Students; Therapeutic; Thinking; Time; Tissues; Transportation; Underrepresented Minority; Underrepresented Populations; United States National Academy of Sciences; Universities; Update; Vaccines; Viral; Woman; Workplace; career; doctoral student; dosimetry; frontier; medical schools; medical specialties; meetings; men; minority scientist; multidisciplinary; particle; posters; prevent; programs; prospective; racial disparity; symposium; transmission process

PROJECT SUMMARY/ABSTRACT The COVID-19 pandemic exposed a critical lack of our understanding the airborne transmission of infectious viral agents. Deficiencies in understanding the deposition, metabolism, distribution in the body, and mechanisms of injury of aerosols (particles suspended in a gas) limit the confidence in setting air quality standards and developing new inhaled therapeutics. The delivered inhaled dose (e.g., mg/target tissues) is poorly understood due to individual differences, the complexity of aerosols, and post inhalation internal events. UC Irvine’s Air Pollution Health Effects Laboratory has been involved in basic and applied research in this area since its founding in the School of Medicine in 1974. It has initiated several topic-focused multi-disciplinary conferences on inhaled aerosols. This proposal requests support for an international conference “Inhaled Aerosol Dosimetry: Advances, Applications and Impacts on Risk Assessments and Therapeutics”, to be held adjacent to the UC Irvine campus at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering, in Irvine, CA 3 days in October of 2024. The conference center offers solid support including an atmosphere conducive to collegiality, inclusion, and creative thinking. The conference will bring together scientists, engineers, medical researchers, regulators, and others who normally attend separate professional meetings, and read specialty journals in relative isolation thereby inhibiting cross-discipline communications and collaborations. Our Organizing Committee of 10 men and 7 women scientists represents universities, governments, and private laboratories. They are aware of critical research needs in medicine, science, and government, as well as gender and racial inequalities. Sessions include; overviews, recent research, complex mixtures; in-vitro methods to reduce the use of live animals; computer model advances; and case studies. Each session is plenary, geared to be understandable by all attendees, and each has discussion time. The program supports cross-discipline communication and collaboration. The registration fee will cover all sessions, and transportation between the nearby airport (SNA), the hotels, and the conference center. Staff will help those with special needs and efforts will be made to attract those from underrepresented groups. Students will have a luncheon with prospective employers, and awards will be made for outstanding student posters. A Proceedings will be published, and a journal issue is planned for those papers that meet peer review standards. Startup support is provided by our University. The total budget is about $155,000, and $25,000 is requested from the NHLBI to help support staff and students, and attract attendees from underrepresented groups. Revised 11-26-2022

项目概要/摘要 COVID-19 大流行暴露了我们对传染性病毒在空气中传播的严重缺乏了解。 对气溶胶的沉积、​​代谢、体内分布和损伤机制了解不足 （悬浮在气体中的颗粒）限制了制定空气质量标准和开发新吸入空气的信心 由于个体差异，对所输送的吸入剂量（例如毫克/靶组织）知之甚少。 气溶胶的复杂性和吸入后内部事件已被加州大学欧文分校的空气污染健康影响实验室研究。 自1974年在医学院成立以来，一直致力于该领域的基础和应用研究。 几个关于吸入气溶胶的主题集中的多学科会议该提案请求支持。 国际会议“吸入气溶胶剂量测定：进展、应用及其对风险评估和影响” Therapeutics”，将在加州大学欧文分校校园附近的国家阿诺德和梅布尔贝克曼中心举行 科学与工程学院，2024 年 10 月 3 天，位于加利福尼亚州欧文市。会议中心提供坚实的基础 会议将带来支持，包括有利于合作、包容和创造性思维的氛围。 科学家、工程师、医学研究人员、监管者和其他通常参加不同专业人员的人在一起 会议和阅读专业期刊相对孤立，从而抑制了跨学科交流和 我们的组委会由 10 名男性科学家和 7 名女性科学家组成，代表大学、政府和机构。 他们了解医学、科学和政府以及性别方面的关键研究需求。 会议包括：概述、最近的研究、减少的复杂体外方法； 活体动物的使用；计算机模型的进展；以及案例研究，每个会议都是全体会议，旨在使人们能够理解。 所有参与者都有讨论时间，该计划支持跨学科的交流和协作。 注册费将涵盖所有会议以及附近机场 (SNA)、酒店和会议中心之间的交通费用 会议中心的工作人员将为有特殊需要的人提供帮助，并努力吸引来自会议中心的人。 代表性不足的群体将与潜在学生共进午餐，并为他们颁发奖项。 优秀的学生海报将被出版，并计划为那些符合要求的论文出版一期期刊。 同行评审标准由我们大学提供启动支持，总预算约为 155,000 美元，其中 25,000 美元。 NHLBI 要求帮助支持教职员工和学生，并吸引来自代表性不足群体的参与者。 修订于 2022 年 11 月 26 日