Core--Animal models

核心--动物模型

• 批准号: 6704854
• 负责人: BAOLI YANG
• 金额: $ 5.01万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-21 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6704854
• 关键词: animal colony; biomedical facility; gene targeting; genetically modified animals; genotype; laboratory mouse

DESCRIPTION (provided by applicant) The purpose of this core is to provide centralized care, breeding, genotyping and quality control of transgenic and knockout animals for use by investigators in the program project. In addition, the core will generate new transgenic and gene targeted mouse models where needed by PPF investigators. The core will also provide a mechanism for the distribution of new experimental transgenic and knockout models to the Jackson Laboratory Induced Mutant Resource, and to program and non-program project investigators both at the University of Iowa and outside the institution. The main responsibilities of the Core will be: * Maintenance of genetic stocks, * Generation of Transgenic and Gene Targeted Mice, * Genotyping transgenic and knockout animals, * Provision of experimental and control mice to investigators, * Quality Control.

描述（由申请人提供） 该核心的目的是提供集中护理、育种、基因分型和质量 控制转基因和基因敲除动物，供研究人员在计划项目中使用。在 此外，该核心将生成新的转基因和基因靶向小鼠模型，其中 PPF 调查人员需要。核心还将提供一种新的分配机制 杰克逊实验室诱导突变体的实验转基因和敲除模型 资源，以及项目和非项目项目研究人员都在大学 爱荷华州和机构外。 核心的主要职责是： * 维持遗传资源， * 转基因和基因靶向小鼠的产生， * 对转基因和基因敲除动物进行基因分型， * 向研究人员提供实验小鼠和对照小鼠， * 质量控制。