CORE--MOUSE

核心--鼠标

• 批准号: 7479134
• 负责人: BAOLI YANG
• 金额: $ 25.73万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479134
• 关键词: Accreditation; Animals; Breeding; Caring; Core Facility; Gene Targeting; Generations; Genetic; Genotype; Institution; Iowa; Knock-out; Laboratories; Maintenance; Modeling; Mus; Oral health; Purpose; Quality Control; Research; Research Personnel; Resources; Transgenic Organisms; Universities; Yang; knockout animal; mouse model; mutant; programs

The purpose of this Mouse Core is to provide centralized care, breeding, genotyping and quality control of transgenic and knockout animals for use by investigators in the program project. In addition, the core will generate new transgenic and gene targeted mouse models where needed by program investigators. The core will also provide a mechanism for the distribution of new experimental transgenic and knockout models to either depository (such as the Jackson Laboratory Induced Mutant Resource) or to other investigators at the University of Iowa and outside the institution. The overall Core is directed by Dr. Baoli Yang, who currently serves as Director of the Gene Targeting Core Facility on the campus at the University of Iowa and who, in the last four years, has been served as Animal Core Director of the Comprehensive Oral Health Research Center of Discovery (COHRCD).

该小鼠核心的目的是提供转基因和基因敲除动物的集中护理、育种、基因分型和质量控制，供项目研究人员使用。此外，该核心还将根据项目研究人员的需要生成新的转基因和基因靶向小鼠模型。该核心还将提供一种机制，用于将新的实验性转基因和敲除模型分发给储存库（例如杰克逊实验室诱导突变体资源）或爱荷华大学和机构外的其他研究人员。整体核心由杨宝利博士指导，他目前担任爱荷华大学校园基因打靶核心设施的主任，并在过去四年中担任综合口腔实验室的动物核心主任健康 发现研究中心（COHRCD）。