Scientific Core C Mouse Resources

科学核心 C 鼠标资源

基本信息

批准号：
9208533
负责人：
Lei Wei
金额：
$ 39万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-02-15 至 2022-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9208533
关键词：
Accreditation American Animal Husbandry Animal Model Animal Technicians Animals Applications Grants Bathing Breeding Calendar Colorimetry Consultations Detection Development Disease Doctor of Philosophy Emergency Situation Equipment Fluorescence Freezing Gel Generations Genetically Modified Animals Genotype Growth Human Resources Hybrids Incubators Indiana Laboratories Laboratory Animals Maintenance Molecular Analysis Morphogenesis Mus Participant Performance Periodicity Photography Power Sources Pregnancy Production Program Research Project Grants Research Personnel Resources Services Societies Southern Blotting System Time Training Transgenic Organisms Ultraviolet Rays Universities Ventricular Veterinarians Water X-Ray Film animal care animal resource cost experience experimental study gel electrophoresis human disease knockout animal medical schools mouse model operation postnatal public health relevance square foot success

项目摘要

ABSTRACT Core C is the Mouse Resources Core. All three Projects will make extensive use of genetically modified mice for their proposed experiments. The purpose of Core C is to provide a centralized localization of the animals, sharing of common breeding stocks, and uniform performance of genotype analyses, which will maximize efficiency and minimize costs associated with the production and maintenance of the mice needed for the proposed experiments. Specific activities of the Core C include (1) assistance in the generation of new genetically modified mouse models; (2) establishment and maintenance of breeding stocks; (3) generation of timed pregnancies; (4) generation of postnatal experimental animals; (5) delivery of experimental animals to the appropriate laboratory for use; (6) distribution of genetically modified mouse models. Core C personnel are well-trained in all aspects of the services to be provided. Given the heavy reliance on genetically modified animals and the proven performance of the Core personnel, the importance of Core C to the success of the Program Project Grant application cannot be overstated. RELEVANCE The major benefit of this Mouse Resources Core to these three Projects is to facilitate development of new animal models and efficient usage of existing animal models of human disease thereby accelerating basic discovery. The benefit of this Core to society is to maximize efficiency and minimize the costs associated with usage of animal models of human disease.

抽象的核心C是鼠标资源核心。这三个项目将广泛使用转基因的小鼠他们提出的实验。核C的目的是提供动物的集中定位，共享共同育种库存和基因型分析的统一性能，这将最大化效率并最大程度地减少与小鼠的生产和维护相关的成本提出的实验所需。核心C的具体活动包括（1）协助生成新的转基因小鼠模型；（2）建立和维护育种股票；（3）定时怀孕的产生；（4）产后实验动物的产生；（5）交货实验动物到适当的实验室使用；（6）转基因小鼠的分布型号。核心C人员在要提供的服务的各个方面都有良好的培训。给定重依靠转基因动物以及核心人员的可靠表现， Core C对计划项目授予应用程序成功的重要性不能被夸大。关联这三个项目的鼠标资源核心的主要好处是促进开发新的动物模型并有效使用人类疾病的动物模型，从而加速了基本发现。该核心对社会的好处是最大化效率并最大程度地降低与动物模型的人类疾病使用。