Core C: Imaging, Molecular Biology & Nanomaterial

核心 C：成像、分子生物学

• 批准号: 10019393
• 负责人: Lei Wei
• 金额: $ 39.6万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10019393
• 关键词: Animal Model; Basic Science; Biomimetics; Budgets; Cells; Centers of Research Excellence; Collaborations; Communities; Consultations; Engineering; Extramural Activities; Funding; Health; Hospital Departments; Image; Investments; Laboratories; Letters; Mission; Molecular; Molecular Biology; Musculoskeletal; Nanotechnology; Orthopedics; Phase; Productivity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Rhode Island; Schools; Scientist; Services; Skeletal system; Technical Expertise; Technology; Tissue Sample; Tissues; Translating; Translational Research; Update; Whole Organism; animal imaging; clinical application; human tissue; instrument; instrumentation; interest; nanomaterials; nanomedicine; novel; repaired; skeletal

Core C: Imaging, Molecular Biology & Nanomedicine Core (IMBN) 7. Project Summary/Abstract The missions of the Imaging, Molecular Biology & Nanomedicine Core (IMBN) are 1) to provide instrument, technical, and expertise services to researchers interested in skeletal health and repair, 2) to maintain state-of- art laboratories in animal imaging, molecular biology and nanomedicine supporting musculoskeletal scientists and clinicians to develop and accomplish high-quality research projects, and 3) to become a financially independent center that can continue to thrive once Phase III comes to an end. Services provided by this Core, since inception during phase I and II, have enhanced the productivity and research capabilities of skeletal system investigators and have provided a competitive advantage in garnering extramural funding. RIH has a made a significant investment in expanding its research infrastructure, as detailed in the overall center organization and management plan of this application. This has generated and sustained enormous interest in utilization of Core services that, together with significant guaranteed co-founding by RIH and Orthopedic Department, will allow sustainability of the IMBN Core during and after the Phase III funding period. We will provide the Core services as follows: 1) Provide sophisticated, state-of-the-art instrumentation in translational research, with emphasis on animal models and human tissue samples, to different projects in the COBRE, 2) Provide technical support and expert consultation in the molecular, cell, tissue, and whole organism levels to Rhode Island biomedical community - including biologists, clinicians and engineers, and 3) Provide cutting- edge nanomaterial and nanotechnology to support investigators translating basic research into clinical applications.

核心 C：成像、分子生物学和纳米医学核心 (IMBN) 7. 项目总结/摘要 成像、分子生物学和纳米医学核心 (IMBN) 的使命是 1) 提供仪器、 为对骨骼健康和修复感兴趣的研究人员提供技术和专业知识服务，2）保持状态 动物成像、分子生物学和纳米医学领域的艺术实验室为肌肉骨骼科学家提供支持 和临床医生开发和完成高质量的研究项目，以及 3) 成为财务上的 一旦第三阶段结束，独立中心可以继续蓬勃发展。该核心提供的服务， 自第一阶段和第二阶段启动以来，提高了骨骼的生产力和研究能力 系统研究人员，并在获得外部资金方面提供了竞争优势。 RIH 有一个 为扩大其研究基础设施进行了大量投资，如整个中心所详述 该应用程序的组织和管理计划。这引起并持续了人们的巨大兴趣 利用核心服务，以及 RIH 和 Orthopedic 共同创立的重要保证 该部将允许 IMBN 核心在第三阶段资助期间和之后保持可持续性。我们将 提供以下核心服务： 1) 提供先进、最先进的翻译仪器 对 COBRE 不同项目的研究，重点是动物模型和人体组织样本，2) 提供分子、细胞、组织、整体生物体水平的技术支持和专家咨询 罗德岛生物医学界 - 包括生物学家、临床医生和工程师，以及 3) 提供切割- 边缘纳米材料和纳米技术支持研究人员将基础研究转化为临床 应用程序。