CORE--Physiology-Animal

核心--生理学-动物

基本信息

批准号：
7491168
负责人：
You-Tang Shen
金额：
$ 52.82万
依托单位：
UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7491168
关键词：
Accreditation Acepromazine Acute Adopted Adult Age Aging Air Alcian Blue American Analgesics Anatomy Anesthesia procedures Animal Housing Animal Husbandry Animal Model Animal Technicians Animals Anterior Anterior Descending Coronary Artery Antibiotics Aorta Apical Apis Area Atropine Automobile Driving Back Backcrossings Bathing Biohazardous Substance Biological Biomedical Research Biopsy Blood Blood Pressure Blood Volume Blood flow Blood gas Body Temperature Body Weight Body Weight decreased Boxing Breathing Breeding Caliber Cannulas Cardiac Cardiac Surgery procedures Cardiac Volume Cardiovascular Surgical Procedures Care given by nurses Caring Carotid Arteries Catheters Cell Death Cessation of life Chemicals Chemistry Chest Chest wall structure Chicago Chloride Ion Chlorides Chronic Chronic Care Clinical Clinical Chemistry Clip Coagulation Process Color Condition Congestive Heart Failure Conscious Constriction procedure Containment Coronary Coronary Stenosis Coronary artery Coronary sinus structure Count Coupling Crossbreeding Cultured Cells Cyanosis DNA Daily Data Databases Deceleration Denervation Dentistry Desire for food Devices Diastole Diastolic blood pressure Dimensions Distal Distant Doctor of Medicine Doctor of Veterinary Medicine Dose Dyes Ear Eating Echocardiography Electrodes End Point Environmental air flow Ethanol Evaluation Experimental Animal Model Failure Family suidae Fasting Fatigue Female Fentanyl Flushing Food Freezing Frequencies Functional disorder Future Gamma counter Gel General Anesthesia Generations Genetically Engineered Mouse Genomics Genotype Goals Gossypium Guidelines Health Heart Heart Atrium Heart Diseases Heart Rate Heart failure Heating Hemorrhage Hemostatic function Hepatitis Histopathology Hour Housing Human Human Resources Hyperemia IACUC Illinois Image Implant Incubated Individual Indwelling Catheter Infarction Infection Infectious Skin Diseases Infusion Pumps Infusion procedures Injection of therapeutic agent Institutes International Intervention Intraperitoneal Injections Intravenous Ischemia Isoflurane Isoproterenol Ketamine Knock-out Label Laboratories Laboratory Animal Medicine Laboratory Animal Production and Facilities Laboratory Animals Laboratory Technicians Larynx Lateral Left Left Ventricular Ejection Fraction Left Ventricular Function Left atrial structure Left ventricular structure Length Life Ligature Limb structure Liquid substance Magnetism Maintenance Manuals Mastication Measurement Measures Medical Imaging Medicine Mental Depression Methods Microinjections Microscope Microspheres Mitral Valve Modeling Molecular Monitor Morphine Mus Muscle Cells Myocardial Myocardial Infarction Myocardial Ischemia Myocardium National Research Council Neck Needles Neonatal Nerve Block New Jersey Nitrogen Norepinephrine Nucleic Acids Numbers Ointments Operative Surgical Procedures Optics Oxygen Patient currently pregnant Pentobarbital Performance Perfusion Personal Satisfaction Pharmacy facility Phase Phenols Phosphate Buffer Phosphotransferases Physical Examination Physiologic intraventricular pressure Physiologic pulse Physiological Physiological reperfusion Physiology Plants Plastics Polyethylene Polyethylenes Polymerase Chain Reaction Positioning Attribute Postoperative Care Postoperative Period Powder dose form Preparation Pressure Transducers Principal Investigator Printing Procedures Protein Overexpression Protocols documentation Pulse taking Quality of life Quarantine Radioactive Range Rate Rattus Records Recovery Reflex action Regulation Relaxation Reperfusion Therapy Reporting Research Research Personnel Respiration Respiratory Failure Rest Right ventricular structure Risk Rivers Robotics Rodent Rodent Model Role Rotation Saline Sampling Science Secure Self Mutilation Sensorcaine Sentinel Sequoia Serologic tests Services Shipping Ships Shivering Side Signal Transduction Silastic Silk Site Skin Slice Societies Solutions Source Southern Blotting Speed Staining method Stains Standards of Weights and Measures Sterility Structure Structure of jugular vein Structure of left gastric vein Study of serum Surface Surgeon Surgical Models Surgical incisions Surgical sutures Sus scrofa System Systole Tail Techniques Technology Telazol Telemetry Temperature Testing Thick Thiopental Sodium Thoracic cavity structure Thoracotomy Time Tissue Sample Tissues Training Transducers Transgenic Animals Transgenic Mice Transgenic Organisms Transudate Triton Tube Ultrasonic Transducer Ultrasonics United States National Institutes of Health Universities VX nerve gas Vendor Venous Venous Pressure level Vent Ventral thoracic nerve structure Ventricular Ventricular septum Vertebrates Veterinarians Videotape Virus Virus Diseases Water Water Supply Week Weight Wild Type Mouse Withdrawal Work Xylazine animal care animal colony animal facility animal resource animal tissue artery occlusion ascending aorta base college cost data acquisition day density design digital drinking exhaust expectancy wave experience external jugular vein feeding foot hemodynamics implant material implantation indexing instrument instrumentation knockout animal left coronary artery male medical schools metabolic abnormality assessment mouse model papillary muscle pressure prevent professor programs pup rectal research study response rib bone structure scapula seal sex size solid state subcutaneous telemetering tissue culture tribromoethanol tumor two-dimensional vocalization wound

项目摘要

Core B, the Physiology/Animal Care Core, will provide services related to the preparation of animal models used in the PPG including surgical preparation of the various pig, and mouse models and the health maintenance of these chronic animal preparations. Animal husbandry, including normal housing and feeding, will be carried out by the Research Animal Facility of UMDNJ - New Jersey Medical School. There are four major functions of Core B. The first component of Core B involves surgical preparation of the large animal models, which is required for Projects 1 and 2. The second component involves surgical preparation of the rodent models, which is required for Projects 3 and 4. In the third component, Core B will provide the animal care required for the animal models, including both the care required for maintaining health in chronically instrumented animals and maintenance of the breeding colonies of transgenic mice. The fourth function is administration, since this core services all projects and interacts closely with the other cores, and must meet the regulatory requirements for animal care. The breakdown is as follows: Projects 1 and 2 will use domestic swine (25 % of Core activity, but 30% of Core costs, for each project), Project 3 will use transgenic mice (30% of Core activity, but 25% of Core costs) (rats will be used for neonatal and adult myocyte culture), Project 4 will use transgenic mice (20% of Core activity, but 15% of Core costs).

核心B（生理/动物护理核心）将提供与准备动物模型的准备的服务 PPG包括各种猪的外科手术准备，小鼠模型以及这些慢性的健康维持动物制剂。畜牧业，包括正常的住房和喂养，将由研究进行 Umdnj的动物设施 - 新泽西医学院。 Core B有四个主要功能。第一个组件核心B涉及大型动物模型的手术准备，这是项目1和2所需的。组件涉及啮齿动物模型的手术准备，这是项目3和4所需的。组件，核心B将提供动物模型所需的动物护理，包括维持长期仪器动物的健康并维持转基因小鼠的繁殖菌落。第四个功能是管理，因为此核心服务所有项目都与其他核心紧密互动，并且必须满足动物护理的监管要求。分解如下：项目1和2将使用国内猪（核心活动的25％，但每个项目的核心成本占30％），项目3将使用转基因小鼠（30％核心活动的25％（核心成本的25％）（大鼠将用于新生儿和成人肌细胞培养物），项目4将使用转基因小鼠（占核心活动的20％，但占核心成本的15％）。