Role of the Orbitofrontal Cortex in Regulating Emotion

眶额皮质在调节情绪中的作用

• 批准号: 6640884
• 负责人: Arthur P SHIMAMURA
• 金额: $ 29.25万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6640884
• 关键词: arousal; attention; choice; clinical research; computed axial tomography; decision making; emotions; evoked potentials; expectancy; functional magnetic resonance imaging; high risk behavior /lifestyle; human subject; neuroregulation; prefrontal lobe /cortex; psychological reinforcement; reversal learning; stroke

DESCRIPTION: (provided by applicant) The broad objective of the research program is to assess the role of the orbitofrontal cortex in emotional control. In recent years, the field of affective neuroscience has been advanced significantly by progress in human functional neuroimaging techniques, in behavioral analyses of neurological patients and in theoretical analyses integrating cognitive and emotional function. These advances have led to the view that the orbitofrontal cortex contributes to a variety of functions, including inhibitory control, reward-feedback expectancy, decision making under high risk, and social awareness. In the proposed research program, a four-pronged analysis will be applied. This analysis will include: 1) neuropsychological assessment of patients with frontal lobe lesions, 2) functional magnetic resonance imaging (fMRI), 3) electrophysiological recording of event-related potentials (ERPs), and 4) development of novel behavioral tests to assess cognitive function associated with emotional control. A theoretical framework, dynamic filtering theory, will be used to guide the research program. It is suggested that the prefrontal cortex acts as a filtering or gating mechanism that controls many aspects of information processing, including stimulus encoding, memory activation, response decision, and emotion. Different regions within the prefrontal cortex monitor and control different aspects of mental function. It is proposed that the orbitofrontal cortex is involved in the monitoring and control of affect and arousal. The advantage of this theoretical framework is that findings and research in the analysis of dorsolateral. prefrontal function can be applied to the analysis of orbitofrontal function. This cognitive neuroscience approach will attempt to provide an understanding of the biological underpinnings of drug abuse. In particular, issues of inhibitory control, reward-feedback analysis, and decision making will be considered in light of issues related to drug abuse, such as compulsions, cue-induced cravings, risk taking behavior.

描述：（由申请人提供） 该研究计划的总体目标是评估 眶额皮质负责情绪控制。近年来，该领域 随着人类科学的进步，情感神经科学得到了显着的进步。 功能神经影像技术在神经系统行为分析中的应用 患者以及整合认知和情感的理论分析 功能。这些进展使人们认为眶额皮质 有助于多种功能，包括抑制控制， 奖励反馈预期、高风险下的决策以及社会 意识。在拟议的研究计划中，将进行四管齐下的分析 应用。该分析将包括：1）神经心理学评估 额叶病变患者，2) 功能磁共振成像 (fMRI), 3) 事件相关电位 (ERP) 的电生理记录， 4）开发新的行为测试来评估认知功能 与情绪控制有关。 将使用动态过滤理论这一理论框架来指导 研究计划。有人认为，前额叶皮层充当 控制信息许多方面的过滤或门控机制 处理，包括刺激编码、记忆激活、反应决策、 和情感。前额皮质内不同区域的监测和控制 心理功能的不同方面。建议眶额 皮质参与情感和唤醒的监测和控制。这 该理论框架的优势在于，该理论框架的发现和研究 背外侧分析。前额叶功能可用于分析 眶额功能。这种认知神经科学方法将尝试 提供对药物滥用的生物学基础的了解。在 特别是抑制控制、奖励反馈分析的问题，以及 将根据与药物滥用有关的问题来考虑决策， 例如强迫行为、提示引起的渴望、冒险行为。