Neural Basis of Perceiving Control: Implications for Emotion Regulation

感知控制的神经基础：对情绪调节的影响

基本信息

批准号：
8118525
负责人：
Lauren Aimee Leotti
金额：
$ 5.13万
依托单位：
RUTGERS THE STATE UNIV OF NJ NEWARK
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8118525
关键词：
Address Adult Affect Affective Animal Experimentation Animals Arousal Attention Aversive Stimulus Behavior Behavioral Belief Biological Brain Brain region Buffers Choice Behavior Choices and Control Cognitive Complex Confounding Factors (Epidemiology)Decision Making Emotional Emotions Environment Environmental Risk Factor Event Excision Exercise Exposure to Face Fostering Foundations Functional Magnetic Resonance Imaging Future Habits Human Incentives Individual Informal Social Control Knowledge Lead Learned Helplessness Link Maintenance Mediating Mental disorders Motor Organism Outcome Parenting behavior Perception Physiology Preparation Process Property Psychopathology Punishment Recording of previous events Recruitment Activity Regulation Relative (related person)Research Research Personnel Rewards Risk Risk Factors Stress Substance abuse problem System Testing Uncertainty Visual Fields avoidance behavior base biological adaptation to stress cognitive control coping design drug development emotion regulation expectation experience hedonic motivated behavior neuromechanism preference psychologic public health relevance relating to nervous system response reward processing

项目摘要

DESCRIPTION (provided by applicant): Converging evidence suggests the perception of control - or the collective beliefs in one's ability to exert control over the environment and to produce desired results - is integral for an individual's general wellbeing. Research has demonstrated that the presence or absence of perceived control can have a significant impact on the regulation of emotion, behavior, and physiology. In fact, the absence of perceived control is believed to be at the core of many psychiatric disorders, such as substance abuse. However, the psychological and neural mechanisms underlying the experience of control and its impact on emotion regulation are not well understood. The proposed research attempts to fill this gap in our knowledge by examining the cognitive and affective processes mediating the experience of control in three fMRI studies. In the proposed studies, perceived control is operationalized as the opportunity to exercise choice, since choice behavior is the means by which organisms exert control over their environments (e.g. selecting where to focus attention in the visual field). By exploiting this simple, yet fundamental basis of perceiving control, we can determine how the perception of control influences our ability to regulate emotional responses to appetitive and aversive stimuli. In Expt 1, we characterize the hedonic experience of choice (Aim 1) by examining brain activity during the anticipation of choice (vs. non-choice), controlling for potential confounding variables related to decision-making, such as differences in response selection, motor preparation, and uncertainty of outcomes. Expt 2 builds on this choice paradigm to assess how the affective experience of choice is modulated by the valence and risk of the potential outcomes. Expt 3 was designed to determine whether prior experience with control and choice moderates emotional responses to future potential rewards and punishments (Aim 2). To test this hypothesis, we will experimentally manipulate prior choice experience between two subject groups and then examine the behavioral and brain responses to potential monetary rewards and punishments under choice and no-choice conditions. We expect the perception of control, as it is exercised through choice behavior, to recruit corticostriatal brain regions involved in the experience of reward and regulation of negative effect. PUBLIC HEALTH RELEVANCE: The proposed research will provide the foundation for understanding how the presence or absence of the perception of control can influence our ability to regulate emotional responses. Thus, the proposed research has significant implications for understanding the psychological and neural mechanisms related to the origin, maintenance, and potential treatment of many psychiatric disorders and substance abuse.

描述（由申请人提供）：融合证据表明，对控制的感知 - 或对环境施加控制能力并产生预期结果的集体信念 - 对于个人的一般福祉而言是不可或缺的。研究表明，感知控制的存在或不存在会对情绪，行为和生理学的调节产生重大影响。实际上，人们认为缺乏感知的控制是许多精神疾病（例如滥用药物）的核心。但是，尚不清楚控制控制经验及其对情绪调节的影响的心理和神经机制。拟议的研究试图通过检查三项FMRI研究中介导控制经验的认知和情感过程来填补这一空白。在拟议的研究中，感知控制的控制是行使选择的机会，因为选择行为是生物体对环境施加控制的手段（例如，选择将注意力集中在视野中）。通过利用这种感知控制的简单但基本的基础，我们可以确定控制感知如何影响我们调节对食用和厌恶刺激的情绪反应的能力。在Expt 1中，我们通过检查选择期间的大脑活动（与非选择性），控制与决策相关的潜在混杂变量（例如响应选择，运动制备和结果的不确定性差异）来表征选择的享乐体经历（AIM 1）（AIM 1）。 Expt 2建立在此选择范式的基础上，以评估选择的情感体验如何受到潜在结果的价和风险的调节。 Expt 3旨在确定先前的控制和选择的经验是否会节省对未来潜在奖励和惩罚的情感反应（AIM 2）。为了检验这一假设，我们将通过实验操纵两个受试者组之间的先前选择经验，然后检查对潜在的货币奖励和惩罚的行为和大脑反应，并在选择和无选择条件下进行。我们希望对控制的看法，因为它是通过选择行为行使的，可以招募参与奖励和调节负面影响的经验的皮质纹状体大脑区域。公共卫生相关性：拟议的研究将为了解控制感知的存在或不存在如何影响我们调节情绪反应的能力。因此，拟议的研究对理解与许多精神疾病和滥用药物的起源，维持和潜在治疗相关的心理和神经机制具有重要意义。