Neural Basis of Perceiving Control: Implications for Emotion Regulation

感知控制的神经基础：对情绪调节的影响

• 批准号: 7908071
• 负责人: Lauren Aimee Leotti
• 金额: $ 4.76万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908071
• 关键词: Affective; Attention; Aversive Stimulus; Behavior; Behavioral; Belief; Brain; Brain region; Choice Behavior; Choices and Control; Cognitive; Confounding Factors (Epidemiology); Decision Making; Emotional; Environment; Exercise; Foundations; Functional Magnetic Resonance Imaging; Future; Individual; Knowledge; Maintenance; Mediating; Mental disorders; Motor; Organism; Outcome; Perception; Physiology; Preparation; Process; Punishment; Recruitment Activity; Regulation; Research; Rewards; Risk; Substance abuse problem; Testing; Uncertainty; Visual Fields; base; design; emotion regulation; experience; hedonic; neuromechanism; psychologic; public health relevance; relating to nervous system; response

DESCRIPTION (provided by applicant): Converging evidence suggests the perception of control - or the collective beliefs in one's ability to exert control over the environment and to produce desired results - is integral for an individual's general wellbeing. Research has demonstrated that the presence or absence of perceived control can have a significant impact on the regulation of emotion, behavior, and physiology. In fact, the absence of perceived control is believed to be at the core of many psychiatric disorders, such as substance abuse. However, the psychological and neural mechanisms underlying the experience of control and its impact on emotion regulation are not well understood. The proposed research attempts to fill this gap in our knowledge by examining the cognitive and affective processes mediating the experience of control in three fMRI studies. In the proposed studies, perceived control is operationalized as the opportunity to exercise choice, since choice behavior is the means by which organisms exert control over their environments (e.g. selecting where to focus attention in the visual field). By exploiting this simple, yet fundamental basis of perceiving control, we can determine how the perception of control influences our ability to regulate emotional responses to appetitive and aversive stimuli. In Expt 1, we characterize the hedonic experience of choice (Aim 1) by examining brain activity during the anticipation of choice (vs. non-choice), controlling for potential confounding variables related to decision-making, such as differences in response selection, motor preparation, and uncertainty of outcomes. Expt 2 builds on this choice paradigm to assess how the affective experience of choice is modulated by the valence and risk of the potential outcomes. Expt 3 was designed to determine whether prior experience with control and choice moderates emotional responses to future potential rewards and punishments (Aim 2). To test this hypothesis, we will experimentally manipulate prior choice experience between two subject groups and then examine the behavioral and brain responses to potential monetary rewards and punishments under choice and no-choice conditions. We expect the perception of control, as it is exercised through choice behavior, to recruit corticostriatal brain regions involved in the experience of reward and regulation of negative effect. PUBLIC HEALTH RELEVANCE: The proposed research will provide the foundation for understanding how the presence or absence of the perception of control can influence our ability to regulate emotional responses. Thus, the proposed research has significant implications for understanding the psychological and neural mechanisms related to the origin, maintenance, and potential treatment of many psychiatric disorders and substance abuse.

描述（由申请人提供）：综合证据表明，控制感——或者对一个人对环境进行控制并产生期望结果的能力的集体信念——对于个人的总体福祉来说是不可或缺的。研究表明，感知控制的存在或不存在会对情绪、行为和生理的调节产生重大影响。事实上，缺乏感知控制被认为是许多精神疾病的核心，例如药物滥用。然而，控制体验背后的心理和神经机制及其对情绪调节的影响尚不清楚。拟议的研究试图通过检查三项功能磁共振成像研究中调节控制体验的认知和情感过程来填补我们的知识空白。在拟议的研究中，感知控制被操作化为行使选择的机会，因为选择行为是有机体对其环境施加控制的手段（例如选择在视野中将注意力集中在哪里）。通过利用这种简单但基本的感知控制基础，我们可以确定控制感知如何影响我们调节对食欲和厌恶刺激的情绪反应的能力。在实验 1 中，我们通过检查预期选择（与非选择）期间的大脑活动来描述选择的享乐体验（目标 1），控制与决策相关的潜在混杂变量，例如反应选择的差异，运动准备和结果的不确定性。实验 2 建立在这种选择范式的基础上，评估选择的情感体验如何受到潜在结果的效价和风险的调节。实验 3 旨在确定先前的控制和选择经验是否会调节对未来潜在奖励和惩罚的情绪反应（目标 2）。为了检验这一假设，我们将通过实验操纵两个受试者组之间的先前选择经验，然后检查在选择和非选择条件下对潜在金钱奖励和惩罚的行为和大脑反应。我们期望通过选择行为来行使控制感，从而招募参与奖励体验和负面影响调节的皮质纹状体大脑区域。 公共卫生相关性： 拟议的研究将为理解控制感的存在或不存在如何影响我们调节情绪反应的能力奠定基础。因此，拟议的研究对于理解与许多精神疾病和药物滥用的起源、维持和潜在治疗相关的心理和神经机制具有重要意义。