Development of diamond film technology electrodes

金刚石膜技术电极的开发

• 批准号: 6736946
• 负责人: ALFRED B BONDS
• 金额: $ 14.35万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6736946
• 关键词: Prosimii; Raman spectrometry; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biotechnology; cats; electronic stimulator; implant; mass spectrometry; microelectrodes; surface coating; technology /technique development; vapor; visual cortex

DESCRIPTION (provided by applicant): The last 20 years have seen two trends that will make the development of new interfaces between man-made devices and the living brain increasingly important. Advances in computational power and robotics have made the practical use of such interfaces possible. The aging of the populations of developing nations will make such interfaces a necessity. The use of electrodes for both recording from and stimulating elements within the nervous system is becoming increasingly important for basic research as well as clinical applications. This is a proposal for the development of an electrode technology that is based on the use of Chemical Deposited Vapor (CVD) diamond film as both an electrode substrate and coating. What is known of the tissue compatibility of diamond film suggests that it is totally inert in physiological environments, and its mechanical strength and reliability is well documented. It is also free of artifact when using MRI imaging. Our fabrication laboratory supports selective ion-implantation of these films in order to make them electrically conductive where necessary. We will design and fabricate both single electrodes with full diamond coating on a tungsten core and multiple electrode arrays with eight sensitive regions, each consisting of an array of 16 microtips. We will test the physical and electrical characteristics of these electrodes in saline and in a typical recording/stimulation scenario involving insertion into cat primary visual cortex. Electrode parameters to be varied include tip size and configuration, doping level and surface texture. To test long-term stability of the material and tissue compatibility, we will implant two of the array electrodes in Bush Baby visual cortex for six months. Performance characteristics will be tested at regular intervals and at explanation time both tissue and electrodes will be examined for any deterioration. Our ultimate goal is to take advantage of this technology for both designs of hitherto impossible configurations (e.g., a fully three dimensional array) as well as development of reliable and safe electrodes suitable for long-term implantation.

描述（由申请人提供）：过去20年来了两种趋势，这将使人造设备和活大脑之间的新接口的发展变得越来越重要。计算能力和机器人技术的进步使这种接口的实际使用成为可能。发展中国家人口的老化将使此类接口成为必要。在神经系统内的记录和刺激元素的使用中，对于基础研究和临床应用，越来越重要。这是基于化学沉积蒸气（CVD）钻石膜作为电极底物和涂层的电极技术开发的建议。关于钻石膜的组织兼容性已知的表明，它在生理环境中完全惰性，并且其机械强度和可靠性已得到充分的文献记载。使用MRI成像时，它也没有伪像。我们的制造实验室支持这些薄膜的选择性离子植入，以使其在必要时进行导电。我们将在钨芯上设计和制造带有全钻石涂层的单电极和具有八个敏感区域的多个电极阵列，每个电极阵列由16个微米阵列组成。我们将测试这些电极在盐水中的物理和电气特性，以及涉及插入CAT主视觉皮层的典型记录/刺激场景。要多样化的电极参数包括尖端尺寸和配置，掺杂水平和表面纹理。为了测试材料和组织兼容性的长期稳定性，我们将在Bush婴儿视觉皮层中植入两个阵列电极六个月。性能特征将定期测试，并在解释时间进行组织和电极检查是否恶化。我们的最终目标是利用这项技术，用于迄今不可能的配置的两种设计（例如，完全三维阵列），以及适合长期植入的可靠和安全电极的开发。