SPATIAL CHARACTERISTICS OF NEURONS IN THE STRIATE CORTEX

纹状皮层神经元的空间特征

• 批准号: 6178793
• 负责人: ALFRED B BONDS
• 金额: $ 24.14万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-09-30 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6178793
• 关键词: action potentials; brain electrical activity; brain mapping; cats; cell cell interaction; immunocytochemistry; intercellular connection; neural information processing; neuroanatomy; neurons; single cell analysis; visual cortex; visual fields; visual pathways; visual stimulus

DESCRIPTION: The primary visual cortex has been thought of as a set of independent, static, quasi-linear visual filters. Evidence now suggests that each cell is a node in a dynamic nonlinear network that has the potential for high-level tasks such as figure-ground discrimination and feature integration. The proposed work is intended to bridge the gap between the single-cell;l and network model of visual cortex by exploring cell behavior in the context of activity across groups of cells. This will be done in three ways: (1) modified reverse correlation and dual stimulation paradigms will be used to create a high-resolution map of the influences of peripheral stimulation on Classical Receptive Field (CRF) response characteristics. Anatomical labels and tracers will be used to determine both the lateral and layer organization of excitatory and inhibitory peripheral pathways. (2) Spike-train oscillation may be a means of identifying salient stimuli. Spike bursting is a viable mechanism for enhancing information transfer between cells. The links between oscillation, bursting and cell coupling will be studied by simultaneously recording activity across groups of 2-6 cells and assessing the relationship between oscillation and bursting, as well as how these mechanisms support synaptic communication. The hypothesis that oscillation represents stimulus salience will be tested by analysis of the modulation of oscillation and connection strength by different stimuli. (3) In addition to the information in a spike train, visual stimuli might be represented by dynamic sub-groups of cells. Simultaneous activity in groups of cells will be observed to see how correlation in their responses changes as a function of different spatial configurations of the stimulus. Responses will be evaluated using type analysis, which detects ensemble coding and determines whether it is based on spike rate or synchronization. The question of whether non-linear influences on the cortical response are calculated locally (unique to the cell) or globally (common to the group) will be examined by seeing if different stimuli cause common changes in synaptic effectiveness throughout a group. This work is fundamental to understanding the distributed representation of sensory information in the brain.

描述：主要视觉皮层被认为是一组 独立，静态，准线性视觉过滤器。 现在有证据表明 每个单元格是一个动态非线性网络中的节点 高级任务的潜力，例如图形歧视和 功能集成。 拟议的工作旨在弥合差距 通过探索单细胞; L和视觉皮层网络模型 细胞行为在跨细胞组的活动背景下。 这会 以三种方式完成：（1）修改后的反向相关和双重相关性 刺激范例将用于创建高分辨率图 外周刺激对经典接受场（CRF）的影响 响应特征。 解剖标签和示踪剂将用于 确定兴奋性的横向和层组织和 抑制性周围途径。 （2）尖峰训练振荡可能是一种手段 识别显着刺激。 尖峰破裂是可行的机制 增强细胞之间的信息传递。 之间的链接 振荡，破裂和细胞耦合将同时研究 跨2-6个细胞组记录活动并评估关系 在振荡和破裂之间以及这些机制如何支持 突触通信。 振荡代表刺激的假设 显着性将通过分析振荡的调节和 通过不同刺激的连接强度。 （3）除了 在尖峰火车中的信息，视觉刺激可能由动态表示 细胞的亚组。 将观察到在细胞组中同时活性，以了解如何 其响应的相关性随着不同空间的函数而变化 刺激的配置。 将使用类型评估响应 分析，检测集合编码并确定是否基于 关于尖峰速率或同步。 是否非线性的问题 对皮质反应的影响是在局部计算的（在 通过查看是否是否检查）或全球（组通用） 不同的刺激会导致整个突触有效性的常见变化 一个小组。 这项工作是理解分布式的基础 大脑中感觉信息的表示。