SPATIAL CHARACTERISTICS OF NEURONS IN THE STRIATE CORTEX

纹状皮层神经元的空间特征

• 批准号: 2158914
• 负责人: ALFRED B BONDS
• 金额: $ 12.06万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-09-30 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2158914
• 关键词: action potentials; biological models; brain electrical activity; brain mapping; cats; cell cell interaction; gamma aminobutyrate; intercellular connection; neural information processing; neuroanatomy; neuropharmacology; neurotoxins; visual cortex; visual fields; visual pathways; visual stimulus

The broad goal of this experimental program is to understand how neurons in striate cortex encode visual information and how this information is processed by neuronal microcircuits. We will ultimately express this knowledge in a model that embodies cortical architecture, the function of individual cells, the coding of visual information and the interactions between cells. We believe that the next major progress in understanding the processing of visual information, and brain function in general, will result from the study of the interaction of cells within cortical networks. We propose a program that coordinates investigation of network influences on response properties, observation of the interaction between cells as these influences are realized, delineation of anatomical pathways specific to these interactions and expression of these results in a comprehensive, quantitative model. The program has three related parts. Natural vision involves complex stimuli, so we will assess the influence of network interactions resulting from stimuli with two or more components on the structure of cortical receptive fields in the cat. We will try to localize the origin of stimulus-based reorganization of the receptive fields within the cortical layer structure by testing while pharmacologically blocking the activity of other specific regions. In these experiments, by injection of biocytin at the blocking site we will identify the morphology of the cells involved as well as trace the anatomical pathways from the blocking site to the recording site. We will also test for the presence of GABA at these sites. The second goal of the program is to study how functional connectivity within the cortical network depends on the nature of the stimulation. We will simultaneously record from coupled neurons using a method of spike discrimination to determine the relative effectiveness of single spikes and spike bursting in intracortical communication. These experiments will also help us to understand the extent to which changes in cell-to-cell communication are responsible for receptive field filter characteristics and adaptive effects that are spatially- or contrast-dependent. The third goal is to express our findings in the form of a quantitative, realistic model that will include both pyramidal and stellate cells, layered organization, complex membrane mechanisms and network interactions dictated by our previous results and the results of others. The development of the model and experimental planning will be interactive, with experiments suggesting new aspects of the model and the model suggesting new types of experiments.

该实验计划的广泛目标是了解神经元如何 在条纹皮层中编码视觉信息以及此信息的方式 由神经元微电路处理。我们最终将表达这一点 在体现皮质体系结构的模型中的知识， 单个单元格，视觉信息的编码和相互作用 在细胞之间。我们认为，理解的下一个重大进展 视觉信息的处理以及大脑功能通常将 由皮质中细胞相互作用的研究产生 网络。 我们提出了一个协调网络调查的程序 对响应特性的影响，观察到的相互作用 由于实现这些影响，细胞的描述是解剖途径 特定于这些相互作用和这些结果的表达 全面的定量模型。该程序有三个相关的部分。 自然视力涉及复杂的刺激，因此我们将评估影响 由两个或多个组件刺激产生的网络相互作用 关于猫中皮质接受场的结构。我们将尝试 将基于刺激的重组的起源定位 通过测试，在皮层结构内的字段 药理阻止其他特定区域的活性。在 这些实验，通过在阻塞部位注入生物细胞素，我们将 识别所涉及的细胞的形态以及跟踪 从阻塞站点到记录站点的解剖途径。我们将 还测试在这些地点是否存在GABA。第二个目标 程序是研究皮质内的功能连通性 网络取决于刺激的性质。我们将同时 使用一种尖峰歧视方法从耦合神经元记录到 确定单个尖峰和尖峰破裂的相对有效性 在心脏内交流中。这些实验也将帮助我们 了解细胞间通信的变化的程度 负责接受场滤波器特性和自适应 依赖于空间或对比度的效果。第三个目标是 以定量，现实模型的形式表达我们的发现 将包括锥体和星状细胞，分层组织， 复杂的膜机制和网络相互作用由我们的 先前的结果和其他结果。模型的发展 实验计划将是互动的，实验表明 该模型的新方面和模型暗示了新类型的新类型 实验。