Molecular/Mechanical Imaging of Dentin Bonding Substrate

牙本质粘接基质的分子/机械成像

• 批准号: 6669963
• 负责人: YONG WANG
• 金额: $ 11.33万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6669963
• 关键词: Raman spectrometry; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; dental adhesive /sealant; dental bonding material; dental caries; dental material wear; dentin; human tissue; infrared spectrometry; mechanical stress; oral facial restoration material; restorative dentistry; scanning electron microscopy; tensile strength

DESCRIPTION (provided by applicant): The candidate for the proposed "Mentored Quantitative Research Career Award" has multidisciplinary training and research experience in polymer chemistry and materials science. His expertise in the field of polymer chemistry, material science and vibrational spectroscopy has placed him in a unique position to apply this strong knowledge base to the area of biomaterials and biomedical/tissue engineering. The program outlined in this career development application adds a biological/clinical foundation to the candidate's background. The candidate will build his research knowledge, experience and understanding of the biological aspects of oral tissue development, disease processes involving oral and craniofacial tissues, and molecular biologic techniques through a multidisciplinary program that combines education, mentoring and completion of an innovative research study. The candidate's long-term goal is to establish himself as a productive, independent research scientist in biomaterials/tissue engineering with a specific focus on the development of replacement materials for oral and craniofacial tissues. Research activities will be completed in the newly created Center for Research in Interfacial Structure and Properties at the UMKC School of Dentistry. A fundamental goal of the Center, which is under the direction of the candidate's mentors: Drs. Paulette Spencer and J. Lawrence Katz, is to provide a research environment that serves as a catalyst for collaborative investigations focused on applying the principles of biological systems to the hierarchal design, synthesis and application of biomaterials. The candidate proposes to use novel high-resolution analytical techniques for direct in situ detection of the molecular structure and micro-mechanics of the bond formed at the adhesive interface with caries-affected dentin and sclerotic dentin. The work will identify the structure/property characteristics that inhibit the formation of a durable bond at the adhesive interface with these clinically relevant dentin substrates. Results from this work will provide critical, new insight into failure mechanisms at the dentin/adhesive interface; failure that can ultimately lead to premature breakdown of the composite restoration.

描述（由申请人提供）：拟议中的“指导定量研究职业奖”的候选人具有多学科培训和研究经验。他在聚合物化学，材料科学和振动光谱领域的专业知识使他处于独特的位置，将这种强大的知识库应用于生物材料和生物医学/组织工程领域。该职业发展应用程序中概述的计划为候选人的背景增添了生物/临床基础。候选人将通过多学科研究计划，建立涉及口腔和颅面组织的疾病过程，涉及口腔和颅面组织的疾病过程，涉及口腔和颅面生物学技术的疾病过程的研究知识，经验和理解，该过程结合了教育，指导和完成创新研究研究。候选人的长期目标是将自己确立为生物材料/组织工程领域的一名富有成效的独立研究科学家，特别关注口腔和颅面组织的替代材料的开发。研究活动将在UMKC牙科学院的新创建的界面结构研究中心和财产研究中心完成。该中心的基本目标是在候选人的导师的指导下：Drs。 Paulette Spencer和J. Lawrence Katz将提供一个研究环境，作为合作研究的催化剂，重点是将生物系统原理应用于层次设计，合成和生物材料的应用。候选人建议使用新型的高分辨率分析技术直接原位检测与受龋齿影响的牙本质和硬化性牙本质形成的粘合界面形成的键的分子结构和微力学。这项工作将确定与这些临床相关的牙本质底物在粘合剂界面处抑制耐用键的结构/性质特征。这项工作的结果将为牙本质/粘合剂界面的故障机制提供关键的新见解。失败最终会导致复合恢复的过早崩溃。