Multifunctional, Non-thermal Plasmas for Long-lasting Dental Adhesion

多功能非热等离子体可实现持久的牙齿粘合力

• 批准号: 8183962
• 负责人: YONG WANG
• 金额: $ 37.51万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8183962
• 关键词: Accounting; Address; Adhesions; Adhesives; Area; Bacteria; Biodegradation; Charge; Chemicals; Chemistry; Collagen; Collagen Fibril; Communities; Composite Resins; Copper; Dental; Dental Amalgam; Dental caries; Dentin; Dentistry; Diffuse; Disinfection; Effectiveness; Engineering; Ensure; Environment; Esthetics; Expenditure; Failure; Fluorides; Foundations; Free Radicals; Gases; Goals; Health; Healthcare; Human; In Situ; Infiltration; Lead; Link; Longevity; Operative Dentistry; Oral; Patients; Penetration; Peroxides; Plant Resins; Plasma; Polymers; Quality of life; Reaction; Recurrence; Research; Residual state; Resistance; Solid; Solutions; Solvents; Source; Surface; Swelling; System; Techniques; Technology; Time; Tooth structure; Translating; Ursidae Family; Water; Work; base; chemical binding; chemical bond; composite restoration; cost; covalent bond; crosslink; demineralization; density; design; improved; innovation; killings; microorganism; monomer; new technology; novel; oral bacteria; particle; polymerization; premature; restoration; restorative dentistry; seal; sound; stem; treatment effect

DESCRIPTION (provided by applicant): The scientific objective of this proposal is to employ new surface/interface chemistries/functionalities induced by non-thermal plasmas for robust and durable dentin adhesion, thus significantly extending the longevity of resin-based tooth restorations. The proposed research stems from the critical challenge long facing restorative dentistry: dental restorations based on composite resins have a prohibitively high failure rate. One primary reason for the premature failure is the lack of a tight and long-lasting adhesion between the composite resin and the underline dentin. The inability of the current state-of-the-art bonding techniques to form a tight resin/dentin adhesion is due to three major factors. First, the bonding between resin and dentin collagen, which relies on the infiltration and subsequent entanglement of adhesive resins with exposed collagen fibrils, is poor. The micromechanical interlocking mechanism is intrinsically problematic as insufficient penetration, incomplete polymerization and solvent/water swelling all prohibit the formation of a tight adhesion. Second, the stability and quality of the dentin substrates is often poor. When the foundation to which composite resins adhere is itself shaky, achieving long-lasting restoration is not just challenging, but impossible. Third, the strength and quality of infiltrated resin polymers is usually poor due chiefly to the incomplete polymerization of current adhesives under oral environment. In this proposal, multifunctional non-thermal plasmas with judiciously engineered chemistries will be utilized to simultaneously address all three critical issues. Such a novel and multifunctional plasma technique has the following unique features/functions: 1) sterilize the area of cavity, eliminating residual caries-causing microorganisms; 2) enable direct fluoride delivery to dentin substrates to inhibit demineralization/bacterial attack, thus reduce recurrent caries and improve dentin substrate stability; 3) provide controllable plasma chemistries to tailor the surface energy in-situ and on-demand for enhanced adhesive penetration into exposed collagen fibrils; 4) participate in network polymerization and crosslinking reactions in resin matrix, consequently increase the monomer/polymer conversion and crosslinking density of the resin matrix and thus producing a more cohesive and degradation-resistant resin matrix; 5) improve the stability of the dentin substrates against biodegradation through enhanced resin protection; 6) yield a chemical/covalent bonding between adhesive resins and collagen fibrils, thus enhancing the adhesive/dentin bond strength. Various characterization techniques will be utilized to thoroughly elucidate the plasma treatment effects on the dentin and adhesive surface/interface. The goal is not only to confirm that the design principles and the engineered plasma technology/chemistries work, but also gain deep understanding into how and why they do. PUBLIC HEALTH RELEVANCE: Replacement of failed restorations accounts for nearly 75% of all operative dentistry. This translates to 200 million replacements for failed restorations annually in the US. The breakdown has been linked to the failure of our current techniques to develop a durable adhesion to dentin. If we are successful at completing the goals outlined in this project the direct benefits will be more durable dental restorations, increased quality of life and decreased costs to the patient in terms of both time and money.

描述（由申请人提供）：该提案的科学目标是采用由非热等离子体引起的新的表面/界面化学/功能，以实现健壮且耐用的牙本质粘附，从而显着延长了基于树脂的牙齿修复的寿命。拟议的研究源于长期面临恢复性牙科的关键挑战：基于复合树脂的牙科修复体具有高度高的衰竭率。过早失败的主要原因之一是复合树脂和下划线牙本质之间缺乏紧密而持久的粘附。当前最新的粘结技术无法形成紧密的树脂/牙本质粘附，这是由于三个主要因素。首先，树脂和牙本质胶原蛋白之间的键合依赖于浸润和随后用暴露的胶原纤维的粘合剂缠结的粘合物。微机械互锁机制在本质上是有问题的，因为穿透性不足，聚合不完整/溶剂/水肿胀都禁止形成紧密的粘附。其次，牙本质底物的稳定性和质量通常很差。当复合树脂粘附的基础本身摇晃时，实现持久的恢复不仅具有挑战性，而且是不可能的。第三，浸润的树脂聚合物的强度和质量通常由于口服环境下当前粘合剂的不完全聚合而较差。在此提案中，将使用具有明智工程化学的多功能非功能性等离子体来同时解决所有三个关键问题。这种新颖的多功能等离子体技术具有以下独特的功能/功能：1）消毒腔区域，消除了残留的龋齿引起的微生物； 2）使氟化物直接递送至牙本质底物抑制脱矿化/细菌攻击，从而减少复发性龋齿并改善牙本质底物的稳定性； 3）提供可控的等离子体化学分配，以定制原地和点播的表面能，以增强粘合剂渗透到裸露的胶原蛋白原纤维中； 4）参与树脂基质中的网络聚合和交联反应，因此增加了树脂基质的单体/聚合物转化率和交联密度，从而产生了更具凝聚力和更耐降解的树脂矩阵； 5）通过增强的树脂保护提高牙本质底物针对生物降解的稳定性； 6）在粘附树脂和胶原蛋白原纤维之间产生化学/共价键，从而增强了粘合剂/牙本质键的强度。各种表征技术将用于彻底阐明血浆治疗对牙本质和粘合表面/界面的影响。目标不仅是要确认设计原理和工程等离子体技术/化学作用，而且还对它们的工作方式和原因有深刻的了解。 公共卫生相关性：替换失败的修复体占所有手术牙科的75％。这意味着在美国每年进行了2亿次替代。该细分已经与我们当前技术未能开发出对牙本质的耐用粘附的失败有关。如果我们成功完成该项目中概述的目标，那么直接收益将是更耐用的牙齿修复体，增加生活质量并在时间和金钱方面降低了患者的成本。