PDAY CARDIOVASCULAR SPECIMEN AND DATA LIBRARY

PDAY 心血管样本和数据库

• 批准号: 6527175
• 负责人: JACK P STRONG
• 金额: $ 13.19万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6527175
• 关键词: adolescence (12-20); aorta; archives; atherosclerosis; cardiovascular disorder epidemiology; clinical research; coronary artery; coronary disorder; data management; disease /disorder proneness /risk; human data; tissue resource /registry; young adult human (21-34)

DESCRIPTION (Adapted from the applicant's abstract) This project is for the maintenance of the specimen and data base emanating from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) and Risk Factors in Early Human Atherogenesis (RFEHA) studies (PDAY Archive) so that it can be used effectively by investigators for continued study of atherosclerosis during the next five years. PDAY and RFEHA were investigator-initiated multi-center cooperative studies based on a rigidly developed protocol, which had anatomically standardized samples of aorta and coronary arteries of 3,000 young black and white subjects, age 15-34, who died suddenly of trauma. Risk factor data was also obtained in a majority of the cases. So far these studies have yielded over 75 publications by the PDAY group. These reports in turn have generated a widespread enthusiastic response from investigators throughout the scientific community in the U.S. and abroad. Many of these investigators are currently utilizing or planning to utilize the PDAY Archive as a resource for their studies on atherosclerosis and coronary heart disease. This unique resource, the PDAY Archive, should continue to contribute in important ways to our understanding of atherosclerosis, the underlying cause of coronary heart disease (CHD) and most strokes. CHD and stroke are by far the leading cause of debilitating illnesses and death in this country.

描述 （改编自申请人摘要）该项目用于维护 来自病理生物学的样本和数据库 青年动脉粥样硬化 (PDAY) 的决定因素和早期危险因素 人类动脉粥样硬化 (RFEHA) 研究（PDAY 存档）以便可以使用 研究人员有效地继续研究动脉粥样硬化 未来五年。 PDAY 和 RFEHA 是研究者发起的多中心合作研究 基于严格开发的协议，该协议具有解剖学标准化 3,000 名年轻黑人和白人的主动脉和冠状动脉样本 受试者年龄 15-34 岁，因外伤突然死亡。 风险因素数据也 大多数情况下都能获得。 到目前为止，这些研究已经取得了超过 PDAY 集团出版了 75 篇出版物。 这些报告反过来又产生了 得到了各地调查人员的广泛热烈反响 美国和国外的科学界。 这些调查员中的许多人 目前正在利用或计划利用 PDAY Archive 作为 他们关于动脉粥样硬化和冠心病的研究资源。 PDAY 档案这个独特的资源应该继续为以下领域做出贡献： 我们了解动脉粥样硬化及其根本原因的重要途径 冠心病 (CHD) 和大多数中风。 迄今为止，冠心病和中风 这个国家的衰弱性疾病和死亡的主要原因。