PDAY Cardiovascular Specimen and Data Library

PDAY 心血管样本和数据库

• 批准号: 6611736
• 负责人: JACK P STRONG
• 金额: $ 17.75万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6611736
• 关键词: African American; adolescence (12-20); archives; artery; atherosclerosis; cardiovascular disorder epidemiology; caucasian American; clinical research; coronary disorder; data management; human data; human tissue; tissue resource /registry; young adult human (21-34)

DESCRIPTION (provided by applicant): This project is for the maintenance of the specimen and data base, the PDAY Archive, emanating from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) and Risk Factors in Early Human Atherogenesis (RFEHA) studies so that the Archive can continue to be used effectively by investigators for study of atherosclerosis. PDAY and RFEHA were investigator-initiated multi-center cooperative studies based on a rigidly developed protocol, which had anatomically standardized samples of aorta and coronary arteries of 3,000 young black and white subjects, age 15-34, who died suddenly of trauma. Risk factor data was also obtained in a majority of the cases. So far these studies have yielded over 100 publications. These reports in turn generate a widespread enthusiastic response from investigators throughout the scientific community in the U.S. and abroad. Many investigators are currently utilizing the PDAY specimen and data base as a resource for their studies on atherosclerosis and coronary heart disease. This unique resource, the PDAY Archive, continues to contribute in important ways to our understanding of atherosclerosis, the underlying cause of coronary heart disease and most strokes, which are by far the leading cause of debilitating illnesses and death in this country.

描述（由申请人提供）：该项目用于维持标本和数据库，pday档案，来自青年动脉粥样硬化的病理学决定因素（PDAY）（PDAY）的病理学决定因素以及早期人动脉粥样硬化（RFEHA）研究的危险因素，以便研究人员可以继续研究档案的研究人员，以便研究临床临床的研究。 Pday和Rfeha是基于严格开发的方案的研究者发起的多中心合作研究，该方案​​的主动脉和冠状动脉的解剖学样本是3,000名黑白年轻受试者，年龄在15-34岁，他们突然死于创伤。 在大多数情况下，还获得了风险因素数据。 到目前为止，这些研究已经产生了100多个出版物。 这些报告反过来产生了整个美国和国外科学界的调查人员的广泛热情反应。 目前，许多研究人员正在利用PDAY标本和数据库作为有关动脉粥样硬化和冠心病的研究的资源。 这种独特的资源，即Pday档案，继续以重要的方式为我们理解动脉粥样硬化，冠心病的根本原因和大多数中风，这是迄今为止该国疾病和死亡的主要原因。