PDAY CARDIOVASCULAR SPECIMEN AND DATA LIBRARY

PDAY 心血管样本和数据库

• 批准号: 6184793
• 负责人: JACK P STRONG
• 金额: $ 12.43万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6184793
• 关键词: adolescence (12-20); aorta; archives; atherosclerosis; cardiovascular disorder epidemiology; clinical research; coronary artery; coronary disorder; data management; disease /disorder proneness /risk; human data; tissue resource /registry; young adult human (21-34)

DESCRIPTION (Adapted from the applicant's abstract) This project is for the maintenance of the specimen and data base emanating from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) and Risk Factors in Early Human Atherogenesis (RFEHA) studies (PDAY Archive) so that it can be used effectively by investigators for continued study of atherosclerosis during the next five years. PDAY and RFEHA were investigator-initiated multi-center cooperative studies based on a rigidly developed protocol, which had anatomically standardized samples of aorta and coronary arteries of 3,000 young black and white subjects, age 15-34, who died suddenly of trauma. Risk factor data was also obtained in a majority of the cases. So far these studies have yielded over 75 publications by the PDAY group. These reports in turn have generated a widespread enthusiastic response from investigators throughout the scientific community in the U.S. and abroad. Many of these investigators are currently utilizing or planning to utilize the PDAY Archive as a resource for their studies on atherosclerosis and coronary heart disease. This unique resource, the PDAY Archive, should continue to contribute in important ways to our understanding of atherosclerosis, the underlying cause of coronary heart disease (CHD) and most strokes. CHD and stroke are by far the leading cause of debilitating illnesses and death in this country.

描述 （改编自申请人的摘要）该项目用于维护 从病理生物学发出的标本和数据库的 青年动脉粥样硬化的决定因素（pday）和早期风险因素 人动脉粥样硬化（RFEHA）研究（Pday Archive），以便可以使用 研究人员有效地研究了动脉粥样硬化 接下来的五年。 Pday和Rfeha是研究人员发起的多中心合作研究 基于严格开发的协议，该协议具有解剖学标准化 3,000名黑白年轻的主动脉和冠状动脉样本 15-34岁的受试者突然因创伤而死。 风险因素数据也是 在大多数情况下获得。 到目前为止，这些研究已经屈服 Pday Group的75个出版物。 这些报告又产生了 整个调查人员的广泛热情回应 美国和国外的科学界。 这些调查人员中有许多 目前正在利用或计划利用pday档案作为 他们研究动脉粥样硬化和冠心病的资源。 这个独特的资源，即pday档案，应继续做出贡献 我们理解动脉粥样硬化的重要方法，这是根本原因 冠状动脉疾病（CHD）和大多数中风。 CHD和Stroke是迄今为止 该国疾病和死亡的主要原因。