High-Resolution 3D Breast Tomograph for Early Cancer De*

用于早期癌症 De* 的高分辨率 3D 乳房断层扫描

基本信息

批准号：
6668715
负责人：
BRADLEY E PATT
金额：
$ 9.44万
依托单位：
PHOTON IMAGING, INC.
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-27 至 2005-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6668715
关键词：
bioimaging /biomedical imaging biomedical equipment development breast neoplasm /cancer diagnosis breast neoplasms diagnosis design /evaluation image processing mathematical model photomultiplier scintillation cameras single photon emission computed tomography

项目摘要

DESCRIPTION (provided by applicant): This application is in response to NCI Program Announcement Number PAR-01-102 for proof of feasibility and development of novel imaging technologies for early detection, screening, diagnosis or image guided treatment of cancer. The ultimate goal of the proposal is to develop a compact, tomographic gamma camera for functional and quantitative imaging of breast cancer. The proposed camera will achieve unprecedented spatial resolution and will be used with a novel gantry system that accommodates complex tomographic orbits to fully sample the breast volume and axillary regions. Statistically based image reconstruction methods that model the physics of the acquisition system and reconstruct complex orbits will provide great flexibility in acquisition and processing system images. The innovative geometrical design will allow measurement of absolute quantitative uptake values and localize lesions in 3D volume. The objective in Phase I will be to construct and characterize the compact high-resolution gamma camera and tomographic gantry and reconstruction system. The performance goals of the system are: a 15 cm x 20 cm camera with intrinsic resolution of 1.5 mm, and a spectral resolution of 10% to 12% FWHM for 140 keV gamma-rays. The optimal tomographic orbits for volumetric breast imaging shall be determined during Phase I. Clinical trials and biopsy guidance will be performed during phase II.

描述（由申请人提供）：此申请是响应NCI计划公告编号PAR-01-102 为了证明新颖成像技术的可行性和开发癌症的早期检测，筛查，诊断或图像指导治疗。该提案的最终目标是开发紧凑的层析成像伽玛用于乳腺癌功能和定量成像的相机。提议相机将实现前所未有的空间分辨率，并将与可容纳复杂层析成像轨道的新型龙门系统采样乳房体积和腋窝区域。基于统计的图像重建方法对采集系统的物理学进行建模和重建复杂的轨道将在获取方面具有极大的灵活性和处理系统图像。创新的几何设计将允许测量绝对定量摄取值并将病变定位在3D中体积。我将在阶段的目标是构建和表征紧凑的高分辨率伽马摄像头和断层扫描和重建系统。系统的性能目标是：15厘米x 20厘米的相机固有分辨率为1.5毫米，光谱分辨率为10％至12％FWHM 140个凯夫伽玛射线。体积乳房的最佳断层轨道轨道成像应在第一阶段确定。临床试验和活检指导将在第二阶段进行。