Animal SPECT camera for functional microimaging of brain

用于大脑功能显微成像的动物 SPECT 相机

• 批准号: 6931855
• 负责人: BRADLEY E PATT
• 金额: $ 19.08万
• 依托单位: GAMMA MEDICA-IDEAS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6931855
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; computer simulation; image enhancement; image processing; miniature biomedical equipment; scintillation cameras; semiconduction; single photon emission computed tomography

DESCRIPTION (provided by applicant): This is a proposal to develop a very high-resolution gamma ray Single Photon Emission Computed Tomography (SPECT) camera capable of imaging a wide variety of laboratory animals, from the brain of non-human primates to the whole body of a rat or mouse. The system also includes high-resolution x-ray Computed Tomography (CT) imaging capability of the same subject volume as the SPECT scanner. The imaging characteristics will surpass those of current clinical systems by employing an innovative gamma-ray detector system and collimator geometry that is designed specifically for this application. The camera developed here will meet a new and increasing demand for higher resolution, quantitative, and functional micro imaging in the laboratory setting. Applications include imaging of the central nervous system of non-human primates for the purposes of furthering our knowledge about the functional processes at the micro-level, developing diagnostic and therapeutic pharmaceuticals, and imaging of other animals for the development of cancer seeking radiopharmaceuticals for both diagnostic and therapeutic purposes. Semiconductor radiation detectors have evolved to the extent that we are now able to replace existing technology with solid-state technology that provides both improved performance and more compact designs. The system will consist of over 9000 16 mm solid-state detector pixels with mean energy resolution of 58% IFWHM at 140 keV This represents improvements in intrinsic spatial resolution and energy resolution of a factor of two compared with conventional gamma cameras. The prototype scanner will be capable of non-invasive, internal, in vivo, quantitative functional and fully 3-dimensional imaging of animals from mice to non-human primate brains.

描述（由申请人提供）： 这是一个提出的建议，可以开发出非常高分辨率的伽马射线单光子发射层析成像（SPECT）摄像头，能够成像各种实验动物，从非人类灵长类动物的大脑到整个大鼠或小鼠的整个身体。该系统还包括与SPECT扫描仪相同的主题体积的高分辨率X射线计算机断层扫描（CT）成像能力。成像特性将通过采用专门为此应用设计的创新γ射线检测器系统和准直数几何形状来超越当前临床系统的成像特征。这里开发的相机将满足实验室环境中对更高分辨率，定量和功能性微观成像的新需求。应用包括非人类灵长类动物的中枢神经系统的成像，以增进我们对微观水平功能过程的了解，开发诊断和治疗性药物，以及其他动物的成像，以开发用于诊断和治疗目的的癌症寻求癌症。半导体辐射探测器已经发展到我们现在能够用固态技术替代现有技术的程度，从而提供了改进的性能和更紧凑的设计。该系统将由9000 16 mm的固态检测器像素组成，平均能量分辨率为58％，如果在140 keV处，这代表了与常规伽马摄像机相比，内在空间分辨率和能量分辨率的改善。原型扫描仪将能够对从小鼠到非人类灵长类动物的动物进行非侵入性，内部，体内，定量功能和完全3维成像。