GSO PET/SPECT Imaging System for Radiopharmaceuticals

用于放射性药物的 GSO PET/SPECT 成像系统

• 批准号: 6444920
• 负责人: BRADLEY E PATT
• 金额: $ 8.1万
• 依托单位: PHOTON IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444920
• 关键词: bioimaging /biomedical imaging; electromagnetic radiation; image processing; positron emission tomography; radiopharmacology; scintillation counter; single photon emission computed tomography; technology /technique development

DESCRIPTION (provided by applicant): This is a proposal to develop a high-resolution combined single photon (SPECT) and positron emission tomograph (PET). The dual PET/SPECT scanner will have excellent spatial resolution and sensitivity making quantitative analysis of in vivo functional animal imaging possible. This scanner will greatly facilitate the development and evaluation of imaging agents and pharmaceuticals that are used for a broad variety of diagnostic, therapeutic, therapy monitoring and experimental purposes. The medical fields that benefit from nuclear emission imaging include cardiology, endocrinology, hematology, oncology, osteology, neurology and genetic manipulation and modeling. The PET/SPECT offers great potential to more effectively evaluate the efficacy of agents by replacing current ex vivo, time consuming and expensive methods with more accurate tests in live rodent models. The PET/SPEC utilizes GSO scintillators that provide the necessary performance for both PET and SPECT which are traditionally separate machines. Recent efforts to combine PET and SPECT on human scanners are widespread. Likewise, there is great interest in animal PET and SPECT. This is the first commercial effort to combine PET and SPECT for animals. An extremely versatile electronics processing and data handling scheme will combine with advanced technology scintillators and photosensors to meet the challenge of combining two imaging modalities with very different performance demands. During Phase I we will assemble 1-inch prototypes of the system detectors and characterize the single photon (at 140 keV) and coincidence (511 keV) response in terms of detector efficiency. Energy resolution, timing resolution, and other important characteristics as a proof of feasibility for the full system will be developed in Phase II.

描述（由申请人提供）：这是开发一个的建议 高分辨率组合单光子（SPECT）和正电子发射断层扫描 （宠物）。双PET/SPECT扫描仪将具有出色的空间分辨率和 敏感性对体内功能动物成像进行定量分析 可能的。该扫描仪将极大地促进开发和评估 成像剂和药品，用于多种多样 诊断，治疗，治疗监测和实验目的。这 受益于核排放成像的医学领域包括心脏病学， 内分泌学，血液学，肿瘤学，骨学，神经病学和遗传学 操纵和建模。宠物/SPECT为更多的潜力提供了巨大的潜力 通过替换电流离体，时间有效地评估剂的功效 在现场啮齿动物模型中使用更准确的测试消耗且昂贵的方法。 PET/SPEC使用提供必要性能的GSO闪烁体 对于传统上是分开的机器的宠物和SPECT。最近的 将宠物和SPECT结合在人类扫描仪上的努力是广泛的。同样地， 对动物宠物和SPECT有极大的兴趣。这是第一个广告 努力将动物的宠物和SPECT结合在一起。一种极其用途的电子产品 处理和数据处理方案将与先进技术结合 闪光灯和光传感器应满足组合两个成像的挑战 性能要求非常不同的方式。 在第一阶段，我们将组装系统检测器的1英寸原型 表征单个光子（在140 keV）和巧合（511 keV）响应 就检测器效率而言。能源分辨率，定时解决以及 其他重要特征以证明完整系统的可行性 将在第二阶段开发。