Diffraction Enhanced Imaging Laboratory Research Machine

衍射增强成像实验室研究机

• 批准号: 6885256
• 负责人: Oliver Joel
• 金额: $ 10万
• 依托单位: NESCH, LLC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6885256
• 关键词: X ray; bioimaging /biomedical imaging; computer human interaction; computer program /software; electromagnetic radiation; image processing; imaging /visualization /scanning; synchrotrons; technology /technique development

DESCRIPTION (provided by applicant): Diffraction enhanced imaging (DEI) is a novel approach to X-ray imaging that has the potential to revolutionize X-ray medical imaging, because of its greater contrast at lower delivered X-ray doses than conventional radiography. DEI relies on measuring tiny angular deflections of a collimated X-ray beam as it passes through the object (patient) in acquiring the images. The capability of DEI to detect low-density features in low-density matrices will make it especially useful in medical diagnoses and research. DEI is currently limited to synchrotron radiation facilities, but the potential impact of this technology in medical imaging research, and subsequently in clinical use, will far exceed the current or projected capacity of available synchrotron beamlines. We propose to develop DEI Laboratory Research Machine for medical imaging research. Its successful development, with acceptable image acquisition times, contrast and resolution would provide the knowledge base necessary for subsequent commercialization - a key to DEI's wider use and development of the imaging technology itself - along with the development of appropriate imaging protocols and methods. This project would thus provide the requisite "springboard technology" for the stepwise development of research instrumentation, clinical diagnosis instrumentation, and possibly clinical screening instrumentation. The specific aims of the Phase I is to develop and demonstrate: 1) Shortening the image acquisition time by using a higher power, higher energy X-ray source; 2) Implementing a sample scanning system to increase field of view; 3) Improving the mechanical stability of the system together with reducing the time for aligning the optical system. Assuming favorable results from phase I, the aims of the Phase II project will be the implementation of: a high-power (60 KW) X-ray source; of a more efficient detector; of a user-friendly GUI; of predictive modeling for simple systems, and of a means of relative image quality quantification.

描述（由申请人提供）：衍射增强成像（DEI）是一种新型的X射线成像方法，具有彻底改变X射线医学成像的潜力，因为它在较低的X射线剂量下的对比度比传统的X线摄影更大。 DEI依赖于测量准直的X射线光束在获取图像时穿过物体（患者）时的微小角度挠度。 DEI检测低密度矩阵中低密度特征的能力将使其在医学诊断和研究中特别有用。 DEI目前仅限于同步辐射设施，但是该技术在医学成像研究中的潜在影响，随后在临床使用中，将远远超过可用同步束线的当前或投影能力。我们建议开发用于医学成像研究的DEI实验室研究机器。它的成功开发，具有可接受的图像获取时间，对比度和解决方案将为后续商业化提供所需的知识基础，这是DEI更广泛使用和开发成像技术本身的关键，以及适当的成像协议和方法的开发。因此，该项目将为研究仪器，临床诊断工具以及可能的临床筛查仪器提供必要的“跳板技术”。第一阶段的具体目的是开发和证明：1）使用更高的功率，更高的能量X射线源来缩短图像的获取时间； 2）实施样品扫描系统以增加视野； 3）提高系统的机械稳定性，并减少对齐光学系统的时间。假设第一阶段的有利结果，第二阶段项目的目的将是：高功率（60 kW）X射线源的实施；更有效的检测器；用户友好的GUI；简单系统的预测建模以及相对图像质量定量的手段。