Next Generation microCT

下一代显微CT

基本信息

批准号：
7500278
负责人：
BRADLEY E PATT
金额：
$ 48.36万
依托单位：
GAMMA MEDICA-IDEAS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-30 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7500278
关键词：
Accounting Address Animals Architecture Area Birds Blood Circulation Cells Characteristics Clinical Color Computers Contrast Media Count Coupled DCNU Data Development Diagnosis Dose Dose-Limiting Elements Evaluation Event Functional Imaging Goals Head Heart Rate Human Image Individual Low Dose Radiation Manufacturer Name Measurable Measures Medical Imaging Medical Research Methodology Methods Modality Mus Noise Output Patient Care Patients Performance Phase Photons Positron-Emission Tomography Radiation Range Rate Rattus Reproducibility Research Resolution Resources Risk Rotation Slice Sorting - Cell Movement Source Specimen Speed Standards of Weights and Measures System Technology Testing Time Tissues Translating Tube Upper arm Variant X-Ray Computed Tomography advanced system clinical application computerized data processing cone-beam computed tomography design detector drug development improved in vivo instrument next generation novel pre-clinical prototype respiratory size soft tissue solid state success tomography

项目摘要

DESCRIPTION (provided by applicant): Commercially available microCT (computed tomography) systems have failed to meet the challenging demands for small animal imaging, beyond the single requirement for good spatial resolution. Specifically, they have failed to take into account that the thousand times smaller volume in mice, compared to humans, is also coupled with ten times faster heart rates, and increased respiratory rates and circulation times. Thus, the currently available systems have been limited to either: (1) in-vivo volume CT, which is primarily useful for co-registration of anatomical and with functional images provided by positron emission tomography (PET) or single photon emission computer tomography (SPECT); or (2) ex-vivo high spatial resolution CT, with sufficient contrast resolution for specimen imaging. However, these commercial systems have all failed to address the significant pre-clinical applications for micro-CT, which require improved tissue contrast, lower dose, and faster acquisition times to allow for dynamic images acquired in small animals and to take full advantage of the use of contrast agents. The goal of this project is to develop a next generation microCT for pre-clinical imaging for drug development and medical research. The system will be designed to provide clinical quality CT images in vivo in mice and rats, with performance specifications optimized to accommodate the demanding requirements of the most critical areas of current medical research. Specifically, the instrument will provide very good spatial resolution, ultra fast frame speeds (< 1 second), and low radiation dose to the subject. This will be achieved utilizing a photon counting mode for x-ray acquisition, instead of the standard current integration mode. The system will be capable of gross energy information and energy binning, and thus will provide "Color-CT(tm)" capability, allowing tissue compositional analysis. To accomplish these advances, the system will feature advanced CdTe solid state detectors, coupled to high speed integrated circuits for signal processing, to achieve performance characteristics not currently possible from conventional technologies used by the major CT manufacturers. In Phase-II, a fast dynamic multi-slice Color-CTTM scanner prototype will be developed, employing multiple detector modules in a novel system design incorporating a very fast x-ray source. This new modality, once established in the microCT marketplace, will undoubtedly translate into human CT scanners, and given the current study volumes of clinical CT, the impact that this project imparts to the field of medical imaging will indeed be dramatic.

描述（由申请人提供）：超出对良好空间分辨率的单一要求，商业上可用的Microct（计算机断层扫描）系统无法满足对小动物成像的挑战性要求。具体而言，他们未能考虑到，与人相比，小鼠的数量较小的千倍也与心率更快，呼吸率和循环时间增加了十倍。因此，当前可用的系统仅限于：（1）体内体积CT，这主要用于解剖学的共同注册以及与正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）提供的功能图像；或（2）EX-VIVO高空间分辨率CT，具有足够的对比度分辨率用于样品成像。但是，这些商业系统都无法解决微型CT的重要临床前应用，这些应用需要改善组织对比度，较低剂量和更快的获取时间，以允许在小动物中获得动态图像，并充分利用对比度的使用。该项目的目的是开发用于药物开发和医学研究的临床前成像的下一代微观。该系统将旨在在小鼠和大鼠的体内提供临床质量的CT图像，并具有优化的性能规格，以适应当前医学研究最关键领域的苛刻要求。具体而言，该仪器将提供非常好的空间分辨率，超快速框架速度（<1秒）和对受试者的低辐射剂量。这将是利用X射线采集的光子计数模式而不是标准电流集成模式来实现的。该系统将能够总体能量信息和能量封装，从而提供“颜色-CT（TM）”能力，从而允许组织组成分析。为了实现这些进步，该系统将配备高级CDTE固态检测器，并耦合到高速集成电路以进行信号处理，以实现主要CT制造商使用的常规技术目前无法使用的性能特征。在第三阶段，将开发快速动态的多型颜色CORTTM扫描仪原型，该原型在具有非常快速的X射线源的新型系统设计中采用了多个检测器模块。这种新的模式曾经在Microct市场中建立，无疑将转化为人类CT扫描仪，并鉴于当前的临床CT研究量，该项目对医学成像领域的影响确实将是巨大的。