Shack-Hartman Corneal Topographer and Aberrometer

Shack-Hartman 角膜地形图仪和像差仪

• 批准号: 6442719
• 负责人: LARRY N THIBOS
• 金额: $ 10.37万
• 依托单位: QUARRYMEN OPTICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6442719
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; cornea; cornea disorder; corneal epithelium; diagnosis design /evaluation; eye disorder diagnosis; human subject; imaging /visualization /scanning; lens; morphometry; ophthalmoscopy

DESCRIPTION (provided by applicant): The long-term objective of our project is to design, build, and market an ophthalmic instrument that simultaneously measures corneal topography and optical aberrations of the human eye using wavefront sensing technology. From these measurements our instrument will provide a complete description of the refractive properties of the anterior cornea, the whole eye, and (by inference the crystalline lens. This optical description will include not only the routine refractive errors of defocus and astigmatism normally measured by present-day optometers and corneal topographers, but will also determine the irregular, higher-order optical aberrations which characterize optically abnormal eyes. Feasibility of the aberrometer component of this dual instrument was proven in a previous STTR grant. The purpose of this Phase-I proposal is to demonstrate feasibility of the corneal topography component by building and testing a prototype instrument using core technology developed with previous STTR support. The major technological advantages of using wavefront sensing technology for corneal topography include: (1) improved performance compared to Placido disk technology, (2) novel assessment of the optical aberrations of the crystalline lens, (3) novel assessment of tear film and keratoconic irregularities, (4) space- and cost-effectiveness derived from application of a single core technology to replace multiple instruments. A combined topographer! aberrometer will help provide wavefront-guided prescriptions for aberration corrections based on inter-ocular lenses, corneal photo-ablative surgery, or contact lenses. The long-term benefits will be improved patient care through improved diagnosis and treatment of optical defects of eyes. PROPOSED COMMERCIAL APPLICATION: Acorneal topographer is a clinical instrument used to map the surface geometry of the cornea of a human eye. Our design of a corneal topographer is based on wavefront sensing technology which has numerous advantages: lower cost, better accuracy, and integrated design with ophthalmic aberrometers. The same basic design concept could also be used to measure surfaces of lenses and mirrors in the optics industry.

描述（由申请人提供）：我们项目的长期目标是 设计，构建和销售同时的眼科仪器 使用人眼的角膜形态和人眼的光差 波前传感技术。通过这些测量，我们的工具将 提供前部折射率的完整描述 角膜，全眼，（通过推断结晶镜头。 描述不仅包括散焦的常规折射错误和 通常通过当前的验光仪和角膜来测量的散光 地形学家，但也将决定不规则的高阶光学 异常眼睛异常的畸变。可行性 在先前的sttr中证明了这种双重仪器的异差分量 授予。该阶段I建议的目的是证明 通过构建和测试原型仪器的角膜形态组件 使用以前的STTR支持开发的核心技术。专业 将波前传感技术用于角膜的技术优势 地形包括：（1）与Placido磁盘相比的性能提高 技术，（2）对晶体光差的新颖评估 镜头，（3）对泪膜和角膜异常不规则的新评估，（4） 由单个核心应用得出的空间和成本效益 更换多种乐器的技术。组合地形师！异常 将有助于提供波前引导的处方，以进行像差校正 基于眼部镜头，角膜光燃烧手术或接触 镜片。长期的福利将通过改善改善患者护理 眼睛光缺陷的诊断和治疗。 拟议的商业应用： Acorneal地形师是一种临床仪器，用于绘制人眼角膜的表面几何形状。 我们的角膜地形设计师的设计基于波前传感技术，该技术具有许多优势：较低的成本，更好的准确性和与眼科异差仪的集成设计。 相同的基本设计概念也可以用于测量光学行业的镜头和镜子的表面。

项目成果

Validation of a combined corneal topographer and aberrometer based on Shack-Hartmann wave-front sensing.

基于 Shack-Hartmann 波前传感的组合角膜地形图仪和像差仪的验证。

• DOI: 10.1364/josaa.21.000683
• 发表时间: 2004
• 期刊: Journal of the Optical Society of America. A, Optics, image science, and vision
• 作者: Zhou,Fan;Hong,Xin;Miller,DonaldT;Thibos,LarryN;Bradley,Arthur
• 通讯作者: Bradley,Arthur