SPATIALLY RESOLVED OPTOMETER FOR HUMAN EYES

人眼空间分辨验光仪

• 批准号: 6015640
• 负责人: LARRY N THIBOS
• 金额: $ 11.83万
• 依托单位: QUARRYMEN OPTICAL, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6015640
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; eye disorder diagnosis; eye refractometry; human subject; image processing; visible light

The long-term goal of our project is to design, build, and market a next-generation optometer for comprehensive measurement of the eye's refractive state. Such an optometer will determine not only the routine refractive errors of defocus and astigmatism normally measured by clinical optometers, but will also determine the higher-order optical aberrations (e.g. coma, spherical aberration, etc.) which characterize abnormal or pathological eyes. In Phase-I of this project, our first aim will be to validate our design concept against accepted clinical standards. This will be done by comparing refractive errors measured on human eyes by our prototype system with results from commercial autorefractors and with subjective refractions determined by an experienced optometrist. Our second aim will be to extend our current measurement techniques to make them robust enough to enable routine measurement of pathological eyes and healthy eyes with abnormally large aberrations. This latter aim will be achieved by collecting, analyzing, and modeling sample data from a representative set of abnormal eyes. The results will provide a basis for discovering and implementing new data processing algorithms through improved understanding of the fundamental optical basis of pathological aberrations. PROPOSED COMMERCIAL APPLICATION This instrument will be useful in basic optometric practice, and in clinical research studies of the optical outcome of refractive surgery, inter-ocular lens implants, corneal pathology (e.g, keratoconus), tear film breakup, contact lens therapy (e.g. orthokeratology), early detection of cataract, or any other treatment or intervention which is expected to have an impact on the optical performance of the eye.

我们项目的长期目标是设计，构建和销售下一代光学计，以全面测量眼睛的折光状态。 这样的光仪不仅将确定通常通过临床验光仪测量的散焦和散光的常规折射误差，而且还将确定表征异常或病态眼睛的较高阶段光学畸变（例如昏迷，球形异常等）。 在该项目的第一阶段中，我们的第一个目标是根据公认的临床标准验证我们的设计概念。这将通过比较我们的原型系统在人眼上测得的折射误差与商业自动折射器的结果以及由经验丰富的验光师确定的主观折射的结果。 我们的第二个目的是扩展我们当前的测量技术，使它们足够强大，以便常规地测量病理眼睛和健康的眼睛，并具有异常大的畸变。 后一个目标将通过收集，分析和建模来自代表性异常眼睛的样本数据来实现。 结果将为发现和实施新的数据处理算法的基础提供基础，通过改进对病理畸变的基本光学基础的理解。该仪器提出的商业应用将在基本的验光实践中以及对屈光手术的光学预后研究，眼部透镜植入物，角膜病理学（例如角膜造影），撕裂膜破裂，接触透镜治疗（例如正常人学），触觉或任何其他治疗效果的早期检测效果的临床研究。