Surface-sensitive Laser Array Detects Breath Alcohol

表面敏感激光阵列检测呼吸酒精

• 批准号: 6589597
• 负责人: EUGENE C AQUINO
• 金额: $ 20万
• 依托单位: AMERICAN RESEARCH CORP OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-27 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6589597
• 关键词: alcoholic beverage consumption; bioengineering /biomedical engineering; biomedical equipment development; blood chemistry; breath tests; diagnosis design /evaluation; lasers; monitoring device; polymers

DESCRIPTION (provided by applicant): A need exists for accurate, self-calibrating instrumentation capable of monitoring in real time the concentration of blood alcohol as evidenced by the alcohol content of exhaled breath. At present instrumentation capable of diagnosing breath alcohol content requires selection of a specific sample time, is not readily amenable to continuous monitoring and does not take into account interferences or interpersonal differences in metabolism. American Research Corporation of Virginia (ARCOVA) proposes the development of a sensitive self-calibrating sensor array that is capable of differentiating components of human breath and is sufficiently small to be embedded in a headset. The proposal is innovative in developing a redundant electronic nose providing a unique response to exhaled breath concentration and capable of storing a record of breath species for later evaluation. Phase I Specific Aims include evaluation of the sensitivity and selectivity of polymer-dye thin films for use on the SSDL for alcohol sensing, design and fabrication of an experimental workstation for the characterization of an engineering model SSDL array sensor head, acquisition of families of test data from simulated breath exhalant and optimization of the electronic nose continuous monitor and conceptual design of the prototype SSDL array personal breath alcohol monitor. In Phase II of the program, a prototype SSDL-array will be constructed and field-tested in preparation for commercialization during Phase III of the program.

描述（由申请人提供）：需要能够实时监测血液酒精浓度（如呼出气中的酒精含量）的准确、自校准仪器。目前，能够诊断呼吸酒精含量的仪器需要选择特定的采样时间，不容易进行连续监测，并且没有考虑新陈代谢的干扰或人际差异。弗吉尼亚美国研究公司 (ARCOVA) 提议开发一种灵敏的自校准传感器阵列，该阵列能够区分人类呼吸的成分，并且足够小，可以嵌入耳机中。该提案在开发冗余电子鼻方面具有创新性，该电子鼻可对呼出气体浓度做出独特的响应，并能够存储呼吸种类的记录以供以后评估。第一阶段的具体目标包括评估用于 SSDL 酒精传感的聚合物染料薄膜的灵敏度和选择性、设计和制造用于表征工程模型 SSDL 阵列传感器头的实验工作站、获取测试系列来自模拟呼气呼出数据、电子鼻连续监测仪优化以及 SSDL 阵列个人呼吸酒精监测仪原型概念设计的数据。在该计划的第二阶段，将建造一个 SSDL 阵列原型并进行现场测试，为该计划的第三阶段的商业化做准备。