Neurolyzer: A Neurophysiologic Alcohol Response Index

Neurolyzer：神经生理酒精反应指数

• 批准号: 6737024
• 负责人: ALAN S GEVINS
• 金额: $ 9.95万
• 依托单位: SAM TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6737024
• 关键词: alcoholic beverage consumption; behavioral /social science research tag; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical automation; biomedical equipment development; brain electrical activity; clinical research; computer program /software; driving while intoxicated; electroencephalography; form /pattern perception; functional ability; human data; monitoring device; neurophysiology; neuropsychological tests; performance

DESCRIPTION (provided by applicant): Alcohol abuse can degrade health, cause accidents and reduce productivity. Alcohol consumption can cause acute behavioral slowing and difficulties in concentrating and sustaining attention. Since the relation between blood alcohol and behavioral impairment differs across individuals, increased understanding of the functional impact of alcohol might be obtained through more direct assessment of the effect of alcohol on the human brain. At present there is no convenient way to gauge the effect of alcohol on brain activity, especially in individuals performing real world tasks or approximations thereof such as simulated driving or flight. Recent technological and scientific advances imply the feasibility of a breakthrough technology, the Neurolyzer, specifically designed for routine, automated measurement of the brain's response to alcohol during complex task performance. Similar to blood-breath alcohol meters, such as the Breathalyzer, that gauge the amount of alcohol consumed, the Neurolyzer will provide a continuous index of the effect of alcohol on the brain. It will be embodied in a low-cost, highly automated turnkey system for recording and analyzing the impact of alcohol on EEG signals, that outputs a continuously updated index of the neuromodulatory effects of alcohol. It will embody accumulated expertise about analysis of EEG signals into automated software that will reduce the labor required to extract such information by orders of magnitude, making direct measurements of brain activity available to alcohol researchers conveniently and inexpensively. Building on past successful projects, Phase I will evaluate key remaining scientific and signal processing issues. If successful, Phase II would produce and evaluate a system capable of monitoring an intoxicated individual while he or she engages in complex activities, enabling systematic study of the neural effects of alcohol in contexts ranging from refined laboratory tasks to simulations of real world activities to social interactions. Because the family of devices to which the Neurolyzer will be added has application in many areas beyond alcohol research, the project has good prospects for commercial success.

描述（由申请人提供）：酗酒会降解健康，导致事故并降低生产力。饮酒会导致急性行为放缓和集中和维持注意力的困难。由于血液酒精与行为障碍之间的关系在个人之间有所不同，因此可以通过更直接地评估酒精对人脑的影响来获得对酒精功能影响的了解。目前，没有方便的方法来衡量酒精对脑活动的影响，尤其是在执行现实世界任务或诸如模拟驾驶或飞行之类的近似值的个人中。最新的技术和科学进步意味着突破性技术的可行性，即神经层专为常规，自动测量大脑对酒精对酒精的反应而设计的神经油解剂，在复杂的任务性能过程​​中。类似于呼吸分析仪等血呼吸的酒精表，该含量的酒精量将提供持续的酒精对大脑影响的指数。它将体现在低成本，高度自动化的交钥匙系统中，用于记录和分析酒精对脑电图信号的影响，该系统输出了酒精神经调节作用的连续更新指数。它将体现有关分析脑电图信号到自动软件中的累积专业知识，这将减少通过数量级来提取此类信息所需的人工，从而直接测量酒精研究人员可用的大脑活动。在过去的成功项目的基础上，第一阶段将评估剩余的科学和信号处理问题的关键。如果成功，第二阶段将产生并评估能够监测醉酒的人在从事复杂活动时监测的系统，从而使酒精在从精致的实验室任务到现实世界活动的模拟到社会的环境中的神经影响有系统地研究互动。由于将在酒精研究以外的许多领域中添加神经油解剂的设备家族，因此该项目在商业成功方面具有良好的前景。