CHILDREN'S NEUROPHYSIOLOGICAL COGNITIVE ASSESSMENT TEST

儿童神经生理认知评估测试

• 批准号: 7105075
• 负责人: ALAN S GEVINS
• 金额: $ 35.3万
• 依托单位: SAM TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-05 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7105075
• 关键词: attention deficit disorder; behavior test; behavioral /social science research tag; brain injury; clinical research; cognition; diagnosis design /evaluation; electroencephalography; epidemiology; epilepsy; human subject; memory; mental health information system; middle childhood (6-11); neurophysiology; neuropsychological tests; patient oriented research; psychometrics; sleep disorders

DESCRIPTION (provided by applicant): Children and adolescents can suffer from a variety of conditions associated with abnormalities in behavior and cognitive brain function. This project will create a tool for assessing cognitive brain function in juvenile populations that is robust, repeatable, and free of cultural bias. It builds on innovative methods we have developed that combine task-related measures of response speed and accuracy with concomitant monitoring of neurophysiologic signals. We have so far established that such combined measures improve sensitivity for detecting the neurocognitive effects of medical treatments, help to separate effects due to variations in level of effort or alertness from those related to the regulation of attention and memory, are stable over time in the absence of developmental or medical changes, and are highly correlated with conventional measures of cognitive ability. However these methods are currently limited to comparing a patient's post-treatment test results to that patient's own pre-treatment baseline. This limitation is analogous to a thermometer that only tells whether a patient's temperature changed from the last measurement or an automobile whose speedometer shows change in miles per hour from yesterday. The current project is concerned with overcoming this limitation by utilizing age-matched reference groups to derive assessments of the neural correlates of sustained attention and working memory that can be used to gauge whether a child's neurocognitive ability is within normal bounds and whether it follows a typically maturational progression when tested repeatedly over an extended period. This will be accomplished in Phase II by collecting and analyzing a normative database that will enable comparison of a child's behavioral and neural responses with those of healthy age-matched peers, as well as comparison of any changes observed over time to those which would be expected as a result of normal maturational processes. The improved measures will then be validated by application to data collected from children with several clinical disorders that affect neurocognitive function including sleep disorders, epilepsy, ADHD and mild traumatic head injury. The resulting method will be embodied in a first-of-its-kind, highly automated Children's Neurophysiologic Cognitive Assessment Test (CNCAT). Because there is a large population of children that could benefit from assessment with the CNCAT in conjunction with their medical care, the test has a promising commercial future.

描述（由申请人提供）：儿童和青少年可能会遭受与行为异常和认知大脑功能异常相关的各种疾病。该项目将创建一种用于评估少年种群中认知大脑功能的工具，该工具具有强大的，可重复的且无文化偏见。它建立在我们开发的创新方法的基础上，将与任务相关的响应速度和准确度的度量与对神经生理学信号的同时监测结合在一起。到目前为止，我们已经确定，这种综合措施提高了检测医疗治疗的神经认知作用的敏感性，由于努力水平或机敏性的变化与与关注和记忆的调节相关的差异，有助于分离效应，在没有发展或医学变化的情况下，随着时间的推移稳定，并且与常规认知能力相关。但是，这些方法目前仅限于将患者的治疗后测试结果与该患者自己的治疗前基线进行比较。这种限制类似于温度计，该温度计仅说明患者的温度是从上一次测量值还是汽车的变化变化，而汽车的车速表显示了从昨天开始显示的每小时每小时几英里的变化。当前的项目与通过使用年龄匹配的参考组来克服这一局限性有关来得出对持续关注和工作记忆的神经相关性的评估，这些神经相关性可用于衡量儿童的神经认知能力是否在正常范围内，并且在长期内反复测试时是否遵循典型的成熟进展。这将在第二阶段通过收集和分析一个规范性数据库来实现，该数据库将使孩子的行为和神经反应与健康年龄匹配的同龄人的行为和神经反应进行比较，并比较随着正常成熟过程而观察到的任何变化的任何变化。然后，将通过将几种影响神经认知功能的儿童收集的数据应用于包括睡眠障碍，癫痫，ADHD和轻度创伤性头部损伤的儿童的数据来验证改进的措施。所得的方法将体现在首个，高度自动化的儿童神经生理学认知评估测试（CNCAT）中。由于有大量儿童可以从CNCAT和他们的医疗服务的评估中受益，因此该测试具有有希望的商业未来。