NEUROLYZER: A NEUROPHYSIOLOGIC ALCOHOL RESPONSE INDEX

NEUROLYZER：神经生理酒精反应指数

• 批准号: 6990304
• 负责人: ALAN S GEVINS
• 金额: $ 35.78万
• 依托单位: SAM TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6990304
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; automated data processing; behavioral /social science research tag; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical automation; biomedical equipment development; brain electrical activity; clinical research; cognition; computer program /software; computer simulation; data quality /integrity; driving while intoxicated; electroencephalography; functional ability; human subject; monitoring device; neurophysiology; neuropsychological tests; neuroregulation; performance; sensory feedback; substance abuse related behavior

DESCRIPTION (provided by applicant): Alcohol abuse can degrade health, cause accidents, and. reduce productivity. Alcohol consumption can cause acute behavioral slowing and difficulties concentrating. Since the relation between blood alcohol and behavioral impairment differs across individuals, increased understanding of the functional impact of alcohol might be obtained through more direct assessment of the effect of alcohol on the human brain. At present there is no convenient way to gauge the effect of alcohol on brain activity, especially in individuals performing real world tasks or approximations thereof such as simulated driving or flight. Recent technological and scientific advances imply the feasibility of a breakthrough technology, the Neurolyzer, specifically designed for routine, automated measurement of the brain's response to alcohol during complex task performance. Like blood-breath alcohol meters that gauge the amount of alcohol consumed, the Neurolyzer will provide a measure of the effect of alcohol on the brain. It will be embodied in an economical, highly-automated system for recording and analyzing the impact of alcohol on neurophysiological brain function signals that outputs a frequently updated index of the neuromodulatory effects of alcohol. It will embody accumulated expertise about analysis of EEG signals into automated software that will reduce the labor required to extract such information by several orders of magnitude, making direct measurements of brain activity available to alcohol researchers conveniently and inexpensively. The Phase I work demonstrated the feasibility of automatically measuring the neurophysiologic effects of alcohol in subjects operating a flight simulator program, and evaluated other critical signal processing issues. In Phase II we will refine our analysis procedures, implement a prototype system, validate the methods in the context of laboratory studies of acute and post-acute- alcohol effects, and deploy a prototype Neurolyzer system in the laboratory of a collaborating scientist for independent evaluation during operation of driving simulators. Although it is targeted at a small but critical research niche, the Neurolyzer is also a member of a family of brain function monitoring devices that have broad application in areas beyond alcohol research; as a result the project has good prospects for commercial success.

描述（由申请人提供）：酗酒会损害健康、导致事故等。降低生产力。饮酒会导致严重的行为迟缓和注意力难以集中。由于血液酒精与行为障碍之间的关系因人而异，因此可以通过更直接地评估酒精对人脑的影响来加深对酒精功能影响的了解。目前还没有方便的方法来衡量酒精对大脑活动的影响，特别是对于执行现实世界任务或类似任务（例如模拟驾驶或飞行）的个体。最近的技术和科学进步意味着突破性技术的可行性，即 Neurolyzer，专门设计用于在执行复杂任务时对大脑对酒精的反应进行常规、自动测量。就像测量酒精消耗量的血呼吸酒精测量仪一样，Neurolyzer 可以测量酒精对大脑的影响。它将体现在一个经济、高度自动化的系统中，用于记录和分析酒精对神经生理学大脑功能信号的影响，该信号输出经常更新的酒精神经调节作用指数。它将把脑电图信号分析方面积累的专业知识融入到自动化软件中，从而将提取此类信息所需的劳动力减少几个数量级，从而使酒精研究人员能够方便且廉价地直接测量大脑活动。第一阶段的工作证明了自动测量酒精对运行飞行模拟器程序的受试者的神经生理学影响的可行性，并评估了其他关键的信号处理问题。在第二阶段，我们将完善我们的分析程序，实施原型系统，在急性和急性酒精效应实验室研究的背景下验证方法，并在合作科学家的实验室中部署原型 Neurolyzer 系统进行独立评估在驾驶模拟器操作期间。虽然 Neurolyzer 的目标市场虽小但很关键，但它也是大脑功能监测设备家族的一员，该设备在酒精研究以外的领域也有广泛的应用。因此，该项目具有良好的商业成功前景。