Innovative Implantable Telemetric Ethanol Biosensor

创新的植入式遥测乙醇生物传感器

• 批准号: 7002026
• 负责人: RH Farahi
• 金额: $ 25万
• 依托单位: TELESENSORS, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-10 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7002026
• 关键词: acetaldehyde; alcoholic beverage consumption; bioengineering /biomedical engineering; biomaterial development /preparation; biosensor device; body temperature; computer data analysis; data collection; ethanol; implant; microprocessor /microchip; miniature biomedical equipment; pharmacokinetics; skin; telemetry

DESCRIPTION (provided by applicant): Innovative technologies for sensitive and selective monitoring of alcohol and its metabolites in humans are of continuing importance to the National Institute of Alcoholism and Alcohol Abuse (NIAAA). Although there has been progress in developing real-time, remote sensors and systems in recent years, the performance of these systems is generally insufficient for demanding applications requiring miniaturized continuous monitoring of body functions (e.g. temperature, heart rate, etc.) along with alcohol and other possible chemical constituents while being unconstrained by conventional monitoring devices. Telesensors Inc. proposes to design, develop, fabricate, test and commercialize a miniaturized, implantable telemetric system for transducing alcohol concentrations and body temperatures in subcutaneous tissue. This system will include onboard data collection and analysis and periodic telemetric reporting of the data to a remote base station for storage and further analysis. The combination of multi-channel sensing and data collection capacity, implantability, micro-miniature size, and physiological calibration, all supported by signal processing software that tailors the measurements made to an individual's pharmacokinetics, best represents the state-of-the-art in bio-medical research sought by NIAAA. The proposed system will promote both research and clinical applications. In particular, the variety of biological signals that future researchers could choose as targets for exploiting unused data collection channels built into the. proposed system promises the opportunity to track the progression of nearly any phase of alcohol related illness. As far as is known, the approach we propose offers the only system for direct, continuous, measurement of alcohol concentrations.

描述（由申请人提供）：用于灵敏和选择性监测人类酒精及其代谢物的创新技术对于国家酒精中毒和酒精滥用研究所 (NIAAA) 始终具有重要意义。尽管近年来在开发实时远程传感器和系统方面取得了进展，但这些系统的性能通常不足以满足需要对身体功能（例如温度、心率等）以及酒精进行小型连续监测的苛刻应用和其他可能的化学成分，同时不受传统监测设备的限制。 Telesensors Inc. 提议设计、开发、制造、测试和商业化一种小型化、植入式遥测系统，用于转换皮下组织中的酒精浓度和体温。该系统将包括机载数据收集和分析以及定期将数据遥测报告到远程基站以进行存储和进一步分析。多通道传感和数据收集能力、可植入性、微型尺寸和生理校准的结合，全部由信号处理软件支持，根据个人的药代动力学定制测量结果，最好地代表了最先进的技术NIAAA 寻求的生物医学研究。所提出的系统将促进研究和临床应用。特别是，未来的研究人员可以选择各种生物信号作为目标，以利用内置的未使用的数据收集通道。拟议的系统有望跟踪几乎任何阶段的酒精相关疾病的进展。据我们所知，我们提出的方法提供了唯一用于直接、连续测量酒精浓度的系统。