XE SPECT & FMRI OF REORGANIZATION POST STROKE

X射线光谱仪

• 批准号: 6324837
• 负责人: GEORG DEUTSCH
• 金额: $ 0.84万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-15 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6324837
• 关键词: bioengineering /biomedical engineering; biomedical resource; communication behavior; magnetic resonance imaging; nervous system

No other primate species develops a language competency approaching that of humans. Thus in some way, human brains are distinct from the brains of other primates. Further, language capacity is not a generic function of cerebral cortex, but of functionally specialized regions. By coordinated study of function by functional MRI and histological study of cortical structure, this project addresses the question, What distinguishes "language" cortex from other cerebral cortex? Support for preliminary studies is provided by a UAB Health Services Foundation Grant. An NIH R01 grant has been applied for. From a population of terminally ill subjects, characterized neuropsychologically and with functional MRI, we will obtain cortical specimens for histological study. Functional MRI will be used to identify cerebral cortical areas involved in semantic processing and those involved in processing auditory stimuli. Preliminary results in three volunteers have established the ability of the visually presented and auditorily presented stimuli to elicit activation observable by fMRI. As a result of these comparisons it will be possible to state what are the neuroanatomical structural features specific for cortical regions functionally specialized for language. The ultimate goal is to determine how the operations of these cerebral cortical areas, with their specific structural features, yields the cognitive product: language.

没有其他灵长类动物发展语言能力 接近人类。 因此，在某种程度上，人的大脑是 与其他灵长类动物的大脑不同。 此外，语言 容量不是大脑皮层的通用功能，而是 功能专业的区域。 通过协调的功能研究 功能性MRI和皮质结构的组织学研究， 项目解决了这个问题，是什么区别“语言”皮质 来自其他脑皮质？ 对初步研究的支持是 由UAB Health Services Foundation Grant提供。 NIH R01赠款 已应用。 来自最终病人的人群 神经心理学和功能性MRI，我们将获得皮质 组织学研究的标本。 功能性MRI将用于 确定与语义处理有关的脑皮质区域 那些参与处理听觉刺激的人。 三名志愿者的初步结果已经建立了 视觉上呈现和调查的刺激的能力 引起fMRI可观察到的激活。 由于这些比较，可以说明 皮质特有的神经解剖结构特征是什么 区域在功能上专门用于语言。 最终目标是 确定这些大脑皮质区域的操作如何 它们的特定结构特征可产生认知产品： 语言。