XE SPECT AND FMR IMAGING OF REORGANIZATION POST STROKE

中风后重组的 XE SPECT 和 FMR 成像

• 批准号: 6521025
• 负责人: GEORG DEUTSCH
• 金额: $ 35.11万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-29 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6521025
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; blood flow measurement; brain imaging /visualization /scanning; brain interhemispheric activity; brain mapping; cerebral ischemia /hypoxia; clinical research; functional ability; functional magnetic resonance imaging; human subject; learning; nervous system regeneration; neuropsychological tests; single photon emission computed tomography; stroke; xenon

DESCRIPTION: (Verbatim from the Applicant's Abstract) This project evaluates the extent to which recovery from stroke depends on restitution of function in temporarily impaired cerebral tissue versus reorganization in unaffected brain. A new, dynamic 133 Xenon clearance single Photon Emission Computed Tomography (SPECT) technique, that provides quantification of absolute rCBF through the entire brain, will be used to separate permanent from temporary brain dysfunction following stroke as well as help identify the extent to which unaffected brain can compensate for permanently damaged function through the rCBF patterns elicited by motor and cognitive tasks. High filed (4.1 Tesla) functional magnetic resonance imaging (fMRI) during additional sensory motor and cognitive tasks will be used to compliment and further refine the regional activation data identified in individual patietns by Xenon SPECT. Xenon SPECT during rest and CO2 stress will initially serve to identify diaschisis in peri-infarct regions by determining the volume of brain tissue with reduced blood flow which is in excess of the measured anatomic infarction size. Xe SPECT and fMRI scans during cognitive task activation will ten be used to examine the functional status of peri-infact regions and address the possibility of reorganization in spared brain. A series of tasks that normally induce hemisphere and region specific rCBF activation will provide evidence for cross-hemispheric of ipsilateral compensation during recovery and will also be used to help assess the status and viability of low flow tissue. 128 unilateral stoke patietns and 40 controls will be followed with all neuroimaging procedures at 1 month, 6 month, and 1 year intervals. Neurological, behavioral and cognitive status evaluations will be conducted at the same intervals, providing correlatable functional status data. The extent to which recovery of function may involve "relearning" by brain regions not affected by the stroke will be assessed by evaluating, in well recovered patients, rCBF patterns during cognitive tasks that were initially compromised. Evaluation will consist of comparison with normal controls performing identical tasks. The overall study will provide rationale, based on physiological measurements, for patient management and rehabilitation strategy, including the use of facilitatory versus compensatory rehabilitation techniques.

描述：（逐字研究申请人的摘要）此项目评估 从中风中恢复的程度取决于恢复功能的恢复 暂时损害了未受影响的大脑中的大脑组织与重组。 新的，动态的133氙气清除单光子发射计算机断层 （SPECT）技术，通过量化绝对RCBF 整个大脑将用于将永久性与临时大脑分开 中风后功能障碍，并帮助确定 未受影响的大脑可以通过 电机和认知任务引起的RCBF模式。高申报（4.1特斯拉） 在其他感觉电动机期间的功能磁共振成像（fMRI） 认知任务将用于补充和进一步完善区域 Xenon Spect在单个pat中识别的激活数据。 在休息和二氧化碳压力期间的氙spect最初将用于识别 通过确定脑组织的体积 血液流量减少，超过了测得的解剖梗塞 尺寸。 XE SPECT和fMRI在认知任务激活期间将使用十个 检查事件周围区域的功能状态并解决 在幸免的大脑中重组的可能性。通常的一系列任务 诱导半球和特定区域的RCBF激活将为证据提供证据 恢复过程中同侧补偿的跨斜膜，也将是 用于评估低流动组织的状态和生存能力。 128单方面 所有神经影像都将遵循Stoke Patietns和40个对照 1个月，6个月和1年间隔的程序。神经，行为 认知状态评估将以相同的间隔进行 提供可相关的功能状态数据。恢复的程度 功能可能涉及不受冲程影响的大脑区域的“重新学习” 将通过评估恢复良好的患者的RCBF模式来评估 在最初受到损害的认知任务中。评估将组成 与执行相同任务的正常对照的比较。总体 研究将根据生理测量为患者提供基本原理 管理和康复策略，包括使用促进性 与补偿性康复技术。