XE SPECT AND FMR IMAGING OF REORGANIZATION POST STROKE

中风后重组的 XE SPECT 和 FMR 成像

• 批准号: 6387867
• 负责人: GEORG DEUTSCH
• 金额: $ 34.34万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-29 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6387867
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; blood flow measurement; brain imaging /visualization /scanning; brain interhemispheric activity; brain mapping; cerebral ischemia /hypoxia; clinical research; functional ability; functional magnetic resonance imaging; human subject; learning; nervous system regeneration; neuropsychological tests; single photon emission computed tomography; stroke; xenon

DESCRIPTION: (Verbatim from the Applicant's Abstract) This project evaluates the extent to which recovery from stroke depends on restitution of function in temporarily impaired cerebral tissue versus reorganization in unaffected brain. A new, dynamic 133 Xenon clearance single Photon Emission Computed Tomography (SPECT) technique, that provides quantification of absolute rCBF through the entire brain, will be used to separate permanent from temporary brain dysfunction following stroke as well as help identify the extent to which unaffected brain can compensate for permanently damaged function through the rCBF patterns elicited by motor and cognitive tasks. High filed (4.1 Tesla) functional magnetic resonance imaging (fMRI) during additional sensory motor and cognitive tasks will be used to compliment and further refine the regional activation data identified in individual patietns by Xenon SPECT. Xenon SPECT during rest and CO2 stress will initially serve to identify diaschisis in peri-infarct regions by determining the volume of brain tissue with reduced blood flow which is in excess of the measured anatomic infarction size. Xe SPECT and fMRI scans during cognitive task activation will ten be used to examine the functional status of peri-infact regions and address the possibility of reorganization in spared brain. A series of tasks that normally induce hemisphere and region specific rCBF activation will provide evidence for cross-hemispheric of ipsilateral compensation during recovery and will also be used to help assess the status and viability of low flow tissue. 128 unilateral stoke patietns and 40 controls will be followed with all neuroimaging procedures at 1 month, 6 month, and 1 year intervals. Neurological, behavioral and cognitive status evaluations will be conducted at the same intervals, providing correlatable functional status data. The extent to which recovery of function may involve "relearning" by brain regions not affected by the stroke will be assessed by evaluating, in well recovered patients, rCBF patterns during cognitive tasks that were initially compromised. Evaluation will consist of comparison with normal controls performing identical tasks. The overall study will provide rationale, based on physiological measurements, for patient management and rehabilitation strategy, including the use of facilitatory versus compensatory rehabilitation techniques.

描述：（逐字摘自申请人摘要）该项目评估 中风的恢复在多大程度上取决于功能的恢复 暂时受损的脑组织与未受影响的大脑的重组。 新型动态 133 氙间隙单光子发射计算机断层扫描 (SPECT) 技术，通过 整个大脑，将用于区分永久大脑和临时大脑 中风后的功能障碍以及帮助确定功能障碍的程度 未受影响的大脑可以通过以下方式补偿永久性受损的功能： 由运动和认知任务引发的 rCBF 模式。高场（4.1 特斯拉） 附加感觉运动期间的功能磁共振成像 (fMRI) 认知任务将用于补充和进一步完善区域 通过 Xenon SPECT 识别个体患者的激活数据。 休息和 CO2 压力期间的氙 SPECT 将首先用于识别 通过确定脑组织的体积来确定梗死周围区域的神经联系联系不全 血流量减少，超过测量的解剖性梗塞 尺寸。认知任务激活过程中将使用 Xe SPECT 和 fMRI 扫描 10 种 检查围事实区域的功能状态并解决 幸存的大脑有可能进行重组。通常情况下的一系列任务 诱导半球和区域特异性 rCBF 激活将为 恢复期间同侧代偿的跨半球，也将 用于帮助评估低流量组织的状态和活力。 128单方面 中风患者和 40 名对照者将接受所有神经影像学检查 每隔 1 个月、6 个月和 1 年执行一次程序。神经学、行为学 认知状态评估将按照相同的时间间隔进行， 提供相关的功能状态数据。恢复的程度 功能可能涉及未受中风影响的大脑区域的“重新学习” 将通过评估康复良好的患者的 rCBF 模式来进行评估 在最初受到损害的认知任务期间。评估将包括 与执行相同任务的正常对照进行比较。整体 研究将为患者提供基于生理测量的基本原理 管理和康复策略，包括使用辅助手段 与补偿性康复技术相比。