XE SPECT & FMRI OF REORGANIZATION POST STROKE

X射线光谱仪

• 批准号: 6123450
• 负责人: GEORG DEUTSCH
• 金额: $ 0.84万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123450
• 关键词: bioengineering /biomedical engineering; biomedical resource; communication behavior; magnetic resonance imaging; nervous system

No other primate species develops a language competency approaching that of humans. Thus in some way, human brains are distinct from the brains of other primates. Further, language capacity is not a generic function of cerebral cortex, but of functionally specialized regions. By coordinated study of function by functional MRI and histological study of cortical structure, this project addresses the question, What distinguishes "language" cortex from other cerebral cortex? Support for preliminary studies is provided by a UAB Health Services Foundation Grant. An NIH R01 grant has been applied for. From a population of terminally ill subjects, characterized neuropsychologically and with functional MRI, we will obtain cortical specimens for histological study. Functional MRI will be used to identify cerebral cortical areas involved in semantic processing and those involved in processing auditory stimuli. Preliminary results in three volunteers have established the ability of the visually presented and auditorily presented stimuli to elicit activation observable by fMRI. As a result of these comparisons it will be possible to state what are the neuroanatomical structural features specific for cortical regions functionally specialized for language. The ultimate goal is to determine how the operations of these cerebral cortical areas, with their specific structural features, yields the cognitive product: language.

没有其他灵长类动物发展出语言能力 接近人类。 因此，在某种程度上，人类的大脑 与其他灵长类动物的大脑不同。 此外，语言 能力不是大脑皮层的一般功能，而是 功能专门化区域。 通过对功能的协调研究 功能性 MRI 和皮质结构的组织学研究，这 项目解决了“语言”皮层的区别是什么的问题 来自其他大脑皮层？ 对初步研究的支持是 由 UAB 健康服务基金会拨款提供。 NIH R01 资助 已申请。 从一群患有绝症的受试者中， 通过神经心理学和功能性 MRI，我们将获得皮质 用于组织学研究的标本。 功能性 MRI 将用于 识别参与语义处理的大脑皮层区域 那些参与处理听觉刺激的人。 三名志愿者的初步结果表明 视觉呈现和听觉呈现的刺激的能力 引发可通过功能磁共振成像观察到的激活。 作为这些比较的结果，可以说明 皮质特有的神经解剖结构特征是什么 功能专门化为语言的区域。 最终目标是 确定这些大脑皮层区域的运作方式 它们特定的结构特征，产生认知产品： 语言。