Opioid Receptor Imaging by PET in Bulimia Nervosa

神经性贪食症阿片受体 PET 成像

• 批准号: 6886701
• 负责人: ANGELA S GUARDA
• 金额: $ 38.38万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6886701
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain; bulimia nervosa; clinical research; cognitive behavior therapy; eating disorders; female; human subject; imaging /visualization /scanning; interview; opioid receptor; positron emission tomography; ultrasound blood flow measurement; women' s health; behavioral /social science research tag; bioimaging /biomedical imaging; brain; bulimia nervosa; clinical research; cognitive behavior therapy; eating disorders; female; human subject; imaging /visualization /scanning; interview; opioid receptor; positron emission tomography; ultrasound blood flow measurement; women' s health

DESCRIPTION (provided by applicant): The cause of bulimia nervosa is incompletely understood however animal and human studies have implicated the endogenous opioid system in feeding behavior. We hypothesize that there are both trait and state-related differences in the distribution and modulation of the opioidergic system that underlie the reinforcing quality inherent in this behavioral disorder. We propose to use positron emission tomography (PET)-scanning to measure mu-opiate receptors in patients with bulimia nervosa before and after treatment and in control women. Pilot data suggest a relationship between opioid receptors and the etiology or symptoms of bulimia. We propose to elucidate this relationship and to examine its change with treatment, specifically with normalization of eating behavior. The specific aims of this study are to: 1) Measure regional brain mu opioid receptors by PET in female patients with bulimia nervosa and matched normal controls. 2) Measure the change in regional mu opioid receptors by PET before and after cognitive behavioral therapy (CBT) of patients with bulimia nervosa It is anticipated that elucidation of the role of the endogenous opioid system in bulimia nervosa will not only help elucidate the etiology of this disorder, but also bring about new approaches to diagnosis, long-term risk assessment, and monitoring of treatment.

描述（由申请人提供）：神经性贪食症的原因尚不完全理解，但是动物和人类研究已牵涉到内源性阿片类药物系统中。我们假设在阿片类系统的分布和调制中既存在性状和与状态有关的差异，又是这种行为障碍固有的加强质量。我们建议使用正电子发射断层扫描（PET） - 扫描来测量神经性神经性贪食症患者在治疗前后和对照妇女中的受体。试验数据表明阿片受体与贪食症的病因或症状之间存在关系。我们建议阐明这种关系并检查其与治疗的变化，特别是与饮食行为的归一化。 这项研究的具体目的是：1）在神经性贪食症和匹配正常对照的女性患者中，PET测量宠物的区域脑MU阿片类药物受体。 2）测量神经性雄性氏菌患者在认知行为治疗（CBT）之前和之后通过PET衡量区域MU受体的变化。预计，阐明内源性阿片类神经中内源性阿片类系统在神经性神经中的作用的作用不仅会帮助您阐明这种疾病的病因，还可以阐明诊断的新方法，并可以评估风险的新方法。