LASER MICRO-BEAM CT SCANNING OF DOSIMETRY GELS

剂量测定凝胶的激光微束 CT 扫描

• 批准号: 6298637
• 负责人: MAREK J MARYANSKI
• 金额: $ 58.82万
• 依托单位: MGS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-15 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6298637
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; computed axial tomography; gel; image enhancement; lasers; nuclear magnetic resonance spectroscopy; phantom model; radiation dosage; radionuclide imaging /scanning

DESCRIPTION (Applicant's abstract verbatim): The long-term goal of this project is to provide radiation therapy departments and equipment vendors with a unique tool for accurate, fast and fully three-dimensional characterization of small radiotherapy fields, whether external beams or brachytherapy, with isotropic spatial resolution on the order of 100 microns. Our system is based on laser micro-beam CT scanning of tissue-equivalent dosimeter gels that change their optical properties in proportion to the absorbed dose. In Phase I we have designed, built and thoroughly tested two different prototypes of the micro-scanner, and have successfully proved the feasibility of our idea. In Phase II we will complete the research and development of the micro-scanner and will engineer various gel phantoms for micro-scanning. We will field-test our system in a clinical environment, and perform thorough dosimetry studies of various small fields and brachytherapy sources of clinical importance, comparing our technique with radiochromic film measurements. In Phase III we will license out the manufacture of our micro-scanner, and concentrate our efforts on manufacturing various gel dosimetry phantoms for high-resolution 3D dosimetry. We believe that our system will find widespread use in QA procedures and in patient treatment verification, wherever very high dose gradients are present in the treatment plan. PROPOSED COMMERCIAL APPLICATION: Not Available

描述（申请人的摘要逐字病）：该项目的长期目标 是为放射治疗部门和设备供应商提供独特的 用于准确，快速和完全三维表征的工具 各向同性 100微米的空间分辨率。我们的系统基于激光 微束CT扫描组织等效剂量计凝胶的扫描 光学特性与吸收剂量成比例。在第一阶段我们有 设计，建造和彻底测试了两个不同的原型 微扫描师，并成功证明了我们想法的可行性。在 第二阶段，我们将完成微扫描仪的研究和开发 将设计各种凝胶幻象以进行微扫描。我们将进行测试 在临床环境中的系统，并对 各种临床重要性的各种小领域和近距离放射治疗来源 将我们的技术与放射性薄膜测量进行比较。在第三阶段我们 将许可我们的微扫描仪的制造，并集中精力 为高分辨率3D制造各种凝胶剂量测定幻象的努力 剂量测定。我们相信我们的系统将在质量检查程序中发现广泛使用 在患者治疗验证中，无论剂量很高的梯度在哪里 存在于治疗计划中。 拟议的商业应用： 无法使用