2-Phase Nanogels for Quantitative 3D Radiation Dosimetry

用于定量 3D 辐射剂量测定的 2 相纳米凝胶

• 批准号: 6694981
• 负责人: MAREK J MARYANSKI
• 金额: $ 24.86万
• 依托单位: MGS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6694981
• 关键词: free radical scavengers; gel; hydropathy; micelles; monomer; nanotechnology; polymerization; radiation dosage; surfactant; technology /technique development

MGS Research has pioneered the development of polymer gel dosimeters, using both MRI and optical CT scanning. Our goal in Phase I will be to prove the feasibility of an innovative two-phase nanostructured polymer gel for quantitative 3D radiation dosimetry. The new gel structure can be described as a "single-hit 3D photon counter" that can be expected to be linear with dose and to be dose-rate independent. Moreover, it will be characterized by greater reproducibility, accuracy and stability of the dose response. As a result, the nanostructured polymer gels will be more suitable than the existing single-phase gels for the quantitative 3D radiation dosimetry and high-precision quality assurance, which are very much needed in intensity modulated and 3D conformal radiation therapy.

MGS研究率先使用MRI和光学CT扫描来开发聚合物凝胶剂量计的开发。我们在阶段的目标是证明用于定量3D辐射剂量测定的创新性两相纳米结构凝胶的可行性。 新的凝胶结构可以描述为“单次打击3D光子计数器”，可以预期与剂量线性和剂量率无关。此外，它的特征是剂量反应的更高可重复性，准确性和稳定性。 结果，用于定量3D辐射剂量测定和高精度质量保证的纳米结构聚合物凝胶将比现有的单相凝胶更合适，在强度调制和3D保形辐射疗法中，这非常需要。